NR2C1 Antikörper (C-Term)
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- Target Alle NR2C1 Antikörper anzeigen
- NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Hund, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NR2C1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- QEKAYVEFQD YITKTYPDDT YRLSRLLLRL PALRLMNATI TEELFFKGLI
- Kreuzreaktivität
- Rind (Kuh), Hund, Huhn, Human, Maus, Ratte (Rattus)
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 92%
- Produktmerkmale
- This is a rabbit polyclonal antibody against NR2C1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human NR2C1
- Top Product
- Discover our top product NR2C1 Primärantikörper
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- Applikationshinweise
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WB Suggested Anti-NR2C1 Antibody Titration: 2.5 µg/mL
ELISA Titer: 1:312500
Positive Control: HCT15 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator. - Kommentare
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Antigen size: 603 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
- Andere Bezeichnung
- NR2C1 (NR2C1 Produkte)
- Synonyme
- TR2 antikoerper, NR2C1 antikoerper, dor2 antikoerper, tr2-11 antikoerper, xDOR2 antikoerper, DKFZp468M0512 antikoerper, si:dkey-183c16.2 antikoerper, zgc:110672 antikoerper, 4831444H07Rik antikoerper, 80.3 antikoerper, Eenr antikoerper, Tr2-11 antikoerper, Tr2 antikoerper, Psg4 antikoerper, TR2-11 antikoerper, PSG9 antikoerper, nr2c1 antikoerper, nuclear receptor subfamily 2 group C member 1 antikoerper, nuclear receptor subfamily 2 group C member 1 S homeolog antikoerper, nuclear receptor subfamily 2, group C, member 1 antikoerper, pregnancy specific beta-1-glycoprotein 4 antikoerper, nuclear receptor subfamily 2 group C member 1 L homeolog antikoerper, NR2C1 antikoerper, nr2c1.S antikoerper, nr2c1 antikoerper, Nr2c1 antikoerper, PSG4 antikoerper, nr2c1.L antikoerper
- Hintergrund
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The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites
Alias Symbols: TR2
Protein Interaction Partner: PSPC1, MBD3, SIN3A, RCOR1, KDM1A, POLD3, TRIM28, RBM39, MTA2, MTA1, HDAC3, NR2C2, SMARCA4, SFPQ, RBBP7, RBBP4, NONO, HDAC2, HDAC1, HCFC1, DNMT1, CHD4, NUDT3, UBC, PML, HDAC4, NRIP1, AR, ESR1,
Protein Size: 603 - Molekulargewicht
- 67 kDa
- Gen-ID
- 7181
- NCBI Accession
- NM_003297, NP_003288
- UniProt
- Q15625
- Pathways
- Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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