NR3C2 Antikörper (C-Term)

Produktnummer ABIN2792564

Produktdetails anti-NR3C2 Antikörper

Target: NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Pferd, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR3C2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VSDLLEFCFY TFRESHALKV EFPAMLVEII SDQLPKVESG NAKPLYFHRK

Kreuzreaktivität: Huhn, Human, Maus, Ratte (Rattus)

Homologie: Cow: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NR3C2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NR3C2

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-NR3C2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:12500
Positive Control: PANC1 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 867 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NR3C2

Target: NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))

Andere Bezeichnung: NR3C2 (NR3C2 Produkte)

Synonyme: mr antikoerper, si:ch211-189l17.1 antikoerper, LOC100302443 antikoerper, NR3C2 antikoerper, LOC443144 antikoerper, MLR antikoerper, MR antikoerper, MCR antikoerper, NR3C2VIT antikoerper, Mlr antikoerper, mlr antikoerper, nuclear receptor subfamily 3, group C, member 2 antikoerper, nuclear receptor subfamily 3 group C member 2 antikoerper, mineralocorticoid receptor antikoerper, nuclear receptor subfamily 3 group C member 2 L homeolog antikoerper, nr3c2 antikoerper, NR3C2 antikoerper, LOC443144 antikoerper, Nr3c2 antikoerper, nr3c2.L antikoerper

Hintergrund: NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Alias Symbols: MR, MCR, MLR, FLJ41052, NR3C2VIT, MGC133092, NR3C2
Protein Interaction Partner: RABAC1, RXRA, HSP90AA1, ACSL1, UBC, SRC, PPP5C, PPID, FKBP5, FKBP4, STUB1, AIP, TRIM24, NRIP1, DNAJC7, CAND1, SUMO1, UBE2I, EIF3I, PROX1, PIAS1, PIAS3, HSPA4, PTGES3, AR, NR3C1, ACTA1, ACTG1,
Protein Size: 867

Molekulargewicht: 94 kDa

Gen-ID: 4306

NCBI Accession: NM_001166104, NP_001159576

UniProt: B0ZBF5

Pathways: ACE Inhibitor Pathway, Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway