CHRNB3 Antikörper (Middle Region)

Produktnummer ABIN2792254

Produktdetails anti-CHRNB3 Antikörper

Target: CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))

Bindungsspezifität: Middle Region

Reaktivität: Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRNB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YDGTMVDLIL INENVDRKDF FDNGEWEILN AKGMKGNRRD GVYSYPFITY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CHRNB3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CHRNB3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 458 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CHRNB3

Target: CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))

Andere Bezeichnung: CHRNB3 (CHRNB3 Produkte)

Synonyme: 5730417K16Rik antikoerper, Acrb3 antikoerper, NACHR antikoerper, CHRNB3 antikoerper, chrnb3 antikoerper, cholinergic receptor nicotinic beta 3 subunit antikoerper, neuronal acetylcholine receptor subunit beta-3 antikoerper, cholinergic receptor, nicotinic, beta polypeptide 3 antikoerper, cholinergic receptor, nicotinic beta 3 L homeolog antikoerper, cholinergic receptor, nicotinic beta 3 antikoerper, cholinergic receptor, nicotinic, beta 3b (neuronal) antikoerper, cholinergic receptor, nicotinic, beta polypeptide 3a antikoerper, CHRNB3 antikoerper, CpipJ_CPIJ012638 antikoerper, Chrnb3 antikoerper, chrnb3.L antikoerper, chrnb3 antikoerper, chrnb3b antikoerper, chrnb3a antikoerper

Hintergrund: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
Protein Size: 458

Molekulargewicht: 53 kDa

Gen-ID: 1142

NCBI Accession: NM_000749, NP_000740

UniProt: Q05901