TRAIL Antikörper (N-Term)

Produktnummer ABIN2792132

Produktdetails anti-TRAIL Antikörper

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Bindungsspezifität: N-Term

Reaktivität: Human, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CFLKEDDSYW DPNDEESMNS PCWQVKWQLR QLVRKMILRT SEETISTVQE

Homologie: Dog: 80%, Human: 100%, Pig: 78%

Produktmerkmale: This is a rabbit polyclonal antibody against TNFSF10. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF10

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Antigen size: 281 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TRAIL Antikörper (ABIN2792132)

Ceballos, Parody, Quiroga, Casella, Francés, Larocca, Carnovale, Alvarez, Carrillo: "FoxO3a nuclear localization and its association with β-catenin and Smads in IFN-α-treated hepatocellular carcinoma cell lines." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 34, Issue 11, pp. 858-69, (2014) (PubMed).

Details zu TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Andere Bezeichnung: TNFSF10 (TNFSF10 Produkte)

Synonyme: APO2L antikoerper, Apo-2L antikoerper, CD253 antikoerper, TL2 antikoerper, TRAIL antikoerper, A330042I21Rik antikoerper, AI448571 antikoerper, APO-2L antikoerper, Ly81 antikoerper, Trail antikoerper, tl2 antikoerper, apo2l antikoerper, cd253 antikoerper, trail antikoerper, apo-2l antikoerper, trail1 antikoerper, xtrail1 antikoerper, tnfsf10l2 antikoerper, zgc:92320 antikoerper, TNLG6A antikoerper, TNF superfamily member 10 antikoerper, tumor necrosis factor (ligand) superfamily, member 10 antikoerper, tumor necrosis factor superfamily member 10 antikoerper, TNF superfamily member 10 S homeolog antikoerper, TNFSF10 antikoerper, Tnfsf10 antikoerper, tnfsf10.S antikoerper, tnfsf10 antikoerper

Hintergrund: TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L
Protein Interaction Partner: CASP8, CASP3, CFLAR, TNFRSF10B, FADD, RIPK1, TRAF2, TNFAIP3, SOCS3, RBM48, TNFRSF10D, TNFRSF10C, TNFRSF10A, TNFSF10, TNFRSF11B, ACP5, IER3, CREBBP, SP3, SP1, HDAC5, HDAC4, HDAC3, HDAC2, HDAC1, HIST3H3,
Protein Size: 281

Molekulargewicht: 33 kDa

Gen-ID: 8743

NCBI Accession: NM_003810, NP_003801

UniProt: P50591

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity