RAF1 Antikörper (Middle Region)

Produktnummer ABIN2792055

Produktdetails anti-RAF1 Antikörper

Target: RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SGTQEKNKIR PRGQRDSSYY WEIEASEVML STRIGSGSFG TVYKGKWHGD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against RAF1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human RAF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RAF1

Target: RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))

Andere Bezeichnung: RAF1 (RAF1 Produkte)

Synonyme: CRAF antikoerper, NS5 antikoerper, Raf-1 antikoerper, c-Raf antikoerper, c-raf antikoerper, craf antikoerper, raf1 antikoerper, RAF1 antikoerper, 6430402F14Rik antikoerper, AA990557 antikoerper, BB129353 antikoerper, Craf1 antikoerper, D830050J10Rik antikoerper, v-Raf antikoerper, raf antikoerper, cRaf antikoerper, Raf-1 proto-oncogene, serine/threonine kinase antikoerper, Raf-1 proto-oncogene, serine/threonine kinase a antikoerper, v-raf-leukemia viral oncogene 1 antikoerper, Raf-1 proto-oncogene, serine/threonine kinase S homeolog antikoerper, RAF1 antikoerper, Raf1 antikoerper, raf1a antikoerper, raf1 antikoerper, raf1.S antikoerper

Hintergrund: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Protein Interaction Partner: Prkab1, FYCO1, NPLOC4, TMEM70, COPS7A, DCAF8, PACSIN3, YWHAQ, RANBP9, RB1, PURA, MAP2K2, MAP2K1, MAPK3, MAPK1, PRKAR1A, MYBPC1, HSP90AA1, AKT1, FAM96B, MRAS, HUWE1, SHOC2, UBC, CDC37, IRS4, GPRASP2, STUB1, SH3KBP1, HIPK4, CDK20, YWHAB, TBXA2R, KRAS, YWHAE
Protein Size: 567

Molekulargewicht: 62 kDa

Gen-ID: 5894

NCBI Accession: XP_005265415

UniProt: B4E0X2

Pathways: MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling, BCR Signaling