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MOB1A Antikörper (C-Term)

MOBKL1B Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2790218
  • Target Alle MOB1A (MOBKL1B) Antikörper anzeigen
    MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
    Bindungsspezifität
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 45
    • 29
    • 19
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund, Zebrafisch (Danio rerio)
    Wirt
    • 42
    • 3
    Kaninchen
    Klonalität
    • 42
    • 3
    Polyklonal
    Konjugat
    • 20
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Dieser MOB1A Antikörper ist unkonjugiert
    Applikation
    • 20
    • 15
    • 9
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    FDSVMQLQEE AHLNTSFKHF IFFVQEFNLI DRRELAPLQE LIEKLGSKDR
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MOB1A. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human MOB1A
    Top Product
    Discover our top product MOBKL1B Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 216 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
    Andere Bezeichnung
    MOB1A (MOBKL1B Produkte)
    Synonyme
    mob1 antikoerper, mob4b antikoerper, MOB1A antikoerper, MOBK1B antikoerper, MOB1 antikoerper, mats1 antikoerper, mobk1b antikoerper, mobkl1b antikoerper, MOBKL1B antikoerper, wu:fv69d04 antikoerper, zgc:56189 antikoerper, C2orf6 antikoerper, MATS1 antikoerper, Mob4B antikoerper, 4022402H07Rik antikoerper, MOB4B antikoerper, Mobk1b antikoerper, Mobkl1b antikoerper, MOB kinase activator 1A L homeolog antikoerper, MOB kinase activator 1A antikoerper, MOB kinase activator 1A pseudogene antikoerper, mob1a.L antikoerper, MOB1A antikoerper, mob1a antikoerper, LOC712156 antikoerper, Mob1a antikoerper
    Hintergrund
    MOB1A is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MOB1A stimulates the kinase activity of STK38 and STK38L. MOB1A acts cooperatively with STK3/MST2 to activate STK38.
    Alias Symbols: C2orf6, FLJ10788, FLJ11595, MATS1, MOB1, MOBK1B, Mob4B, MOBKL1B
    Protein Interaction Partner: FAM9B, CMTM3, SEPT3, FAM118A, KANK2, TDO2, UBC, HECW2, ANKRD52, AMOT, ANKRD44, DOCK7, LRCH3, RASSF5, DOCK8, MOB2, SAV1, LRCH2, DOCK6, THOC2, PPP6R3, CRLF3, IPO11, LATS2, ANKRD28, LRCH1, STK38L, PPP6R1, RASSF2, PPP6R2, LATS1, YWHAH, STK4, STK3, PTPN14, PPP
    Protein Size: 216
    Molekulargewicht
    25 kDa
    Gen-ID
    55233
    NCBI Accession
    NM_018221, NP_060691
    UniProt
    Q9H8S9
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