FCGR3A Antikörper (Middle Region)

Produktnummer ABIN2789545

Produktdetails anti-FCGR3A Antikörper

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FCGR3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DPIHLRCHSW KNTALHKVTY LQNGKGRKYF HHNSDFYIPK ATLKDSGSYF

Homologie: Guinea Pig: 79%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against FCGR3A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 253 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FCGR3A

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Andere Bezeichnung: FCGR3A (FCGR3A Produkte)

Synonyme: CD16 antikoerper, CD16A antikoerper, FCG3 antikoerper, FCGR3 antikoerper, FCGRIII antikoerper, FCR-10 antikoerper, FCRIII antikoerper, FCRIIIA antikoerper, IGFR3 antikoerper, Fcgr4 antikoerper, Fc fragment of IgG receptor IIIa antikoerper, FCGR3A antikoerper, Fcgr3a antikoerper

Hintergrund: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3
Protein Interaction Partner: SYK, ZBTB25, APP, IGHG1, GP6, SHC1, CD4, CD247, ZAP70, LCK, PTPRC, FCER1G, FCGR1A, CD38, APCS,
Protein Size: 253

Molekulargewicht: 27 kDa

Gen-ID: 2214

NCBI Accession: NM_001127596, NP_001121068

UniProt: P08637