HLA-DRB3 Antikörper (C-Term)

Produktnummer ABIN2789532

Produktdetails anti-HLA-DRB3 Antikörper

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Bindungsspezifität: C-Term

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DRB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GFYPGSIEVR WFRNGQEEKA GVVSTGLIQN GDWTFQTLVM LETVPRSGEV

Homologie: Human: 100%, Pig: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-DRB3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 266 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HLA-DRB3

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Andere Bezeichnung: HLA-DRB3 (HLA-DRB3 Produkte)

Synonyme: HLA-DR3B antikoerper, BLA-DRB3 antikoerper, Bota-DRB01 antikoerper, Bota-DRB02 antikoerper, Bota-DRB04 antikoerper, Bota-DRB07 antikoerper, Bota-DRB21 antikoerper, Bota-DRB22 antikoerper, LA-DRB antikoerper, major histocompatibility complex, class II, DR beta 3 antikoerper, major histocompatibility complex, class II, DRB3 antikoerper, HLA-DRB3 antikoerper, BOLA-DRB3 antikoerper

Hintergrund: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Alias Symbols: HLA-DR3B, HLA-DR52, HLA-DRB1, MGC117330
Protein Interaction Partner: CDCA8, MAP3K13, YWHAE, PKM, HSP90AB1, HSP90AA1, HSPA8, MS4A1, ATP1B1, ANXA11, CTAG1B, POMC,
Protein Size: 266

Molekulargewicht: 27 kDa

Gen-ID: 3125

NCBI Accession: NM_022555, NP_072049

UniProt: P13762

Pathways: T-Zell Rezeptor Signalweg, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints