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HLA-DPB1 Antikörper (Middle Region)

HLA-DPB1 Reaktivität: Human, Hund, Kaninchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2789429
  • Target Alle HLA-DPB1 Antikörper anzeigen
    HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))
    Bindungsspezifität
    • 16
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 63
    • 21
    • 3
    • 1
    • 1
    Human, Hund, Kaninchen
    Wirt
    • 50
    • 13
    Kaninchen
    Klonalität
    • 45
    • 18
    Polyklonal
    Konjugat
    • 34
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-DPB1 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 28
    • 27
    • 21
    • 16
    • 13
    • 13
    • 11
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    KRAVPDRMCR HNYELGGPMT LQRRVQPRVN VSPSKKGPLQ HHNLLVCHVT
    Homologie
    Dog: 86%, Human: 100%, Rabbit: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against HLA-DPB1. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Top Product
    Discover our top product HLA-DPB1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 258 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))
    Andere Bezeichnung
    HLA-DPB1 (HLA-DPB1 Produkte)
    Synonyme
    PATR-DPB1 antikoerper, B-LB antikoerper, B-LB2 antikoerper, B-LB21 antikoerper, BLB1 antikoerper, GSP-BLB1 antikoerper, DPB1 antikoerper, HLA-DP antikoerper, HLA-DP1B antikoerper, HLA-DPB antikoerper, major histocompatibility complex, class II, DP beta 1 antikoerper, Major histocompatibility complex class II beta chain BLB1 antikoerper, PATR-DPB1 antikoerper, BLB1 antikoerper, HLA-DPB1 antikoerper
    Hintergrund
    HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
    Alias Symbols: DPB1, HLA-DP1B
    Protein Interaction Partner: LZTS2, TRIP6, LGR4, COPB1, RTN4, ROBO2, HLA-DPA1, CD74,
    Protein Size: 258
    Molekulargewicht
    26 kDa
    Gen-ID
    3115
    NCBI Accession
    NM_002121, NP_002112
    UniProt
    P04440
    Pathways
    T-Zell Rezeptor Signalweg, Cancer Immune Checkpoints
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