COL4a3 Antikörper (Middle Region)

Produktnummer ABIN2788301

Produktdetails anti-COL4a3 Antikörper

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Schwein, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL4a3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DPGQPGPPGE QGPPGRCIEG PRGAQGLPGL NGLKGQQGRR GKTGPKGDPG

Homologie: Cow: 93%, Dog: 91%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 91%, Pig: 93%, Rabbit: 85%, Rat: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against COL4A3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COL4A3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1637 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu COL4a3

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Andere Bezeichnung: COL4A3 (COL4A3 Produkte)

Synonyme: zTumstatin antikoerper, [a]3(IV) antikoerper, alpha3(IV) antikoerper, collagen type IV alpha 3 chain antikoerper, collagen, type IV, alpha 3 antikoerper, COL4A3 antikoerper, col4a3 antikoerper, Col4a3 antikoerper

Hintergrund: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Some exons of this gene are interspersed with exons of an uncharacterized gene which is on the opposite strand.
Alias Symbols: -
Protein Interaction Partner: VHL, UBC, SERPINE2, OSM, MFAP2, FBLN2, FN1, DCN, CD93, MMP9, APP, SAA1, MATN2, TGFBI, CAMK2B, USH2A, ANTXR2, COL4A3BP, HABP2,
Protein Size: 1637

Molekulargewicht: 156 kDa

Gen-ID: 1285

NCBI Accession: NM_031362, NP_112730

UniProt: E7ENN2

Pathways: Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity