RASSF5 Antikörper (C-Term)

Produktnummer ABIN2788157

Produktdetails anti-RASSF5 Antikörper

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SFVLKENETG EVEWDAFSIP ELQNFLTILE KEEQDKIHQL QKKYNKFRQK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against Rassf5. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Rassf5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RASSF5

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Andere Bezeichnung: Rassf5 (RASSF5 Produkte)

Synonyme: Maxp1 antikoerper, NORE1 antikoerper, NORE1A antikoerper, NORE1B antikoerper, RAPL antikoerper, RASSF3 antikoerper, 1300019G20Rik antikoerper, AU042887 antikoerper, Nore1 antikoerper, Nore1A antikoerper, Nore1B antikoerper, Rapl antikoerper, Ras association domain family member 5 antikoerper, Ras association (RalGDS/AF-6) domain family member 5 antikoerper, RASSF5 antikoerper, Rassf5 antikoerper

Hintergrund: Rassf5 is a potental tumor suppressor. It seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. It may be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.
Alias Symbols: 1300019G20Rik, AU042887, Maxp1, Nore1, Nore1A, Nore1B, Rapl
Protein Interaction Partner: Hras,
Protein Size: 413

Molekulargewicht: 47 kDa

Gen-ID: 54354

NCBI Accession: NM_018750, NP_061220

UniProt: Q5EBH1

Pathways: T-Zell Rezeptor Signalweg