PCSK1N Antikörper (N-Term)

Produktnummer ABIN2787977

Produktdetails anti-PCSK1N Antikörper

Target: PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCSK1N Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: STPLRLRRAV PRGEAAGAVQ ELARALAHLL EAERQERARA EAQEAEDQQA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Pcsk1n. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Pcsk1n

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 260 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PCSK1N

Target: PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))

Andere Bezeichnung: Pcsk1n (PCSK1N Produkte)

Synonyme: PROSAAS antikoerper, SAAS antikoerper, Saas antikoerper, AI848336 antikoerper, KEP antikoerper, PEN antikoerper, PEN19 antikoerper, PEN20 antikoerper, Pan3 antikoerper, SAASCT antikoerper, bLEN antikoerper, lLEN antikoerper, proSAAS antikoerper, proprotein convertase subtilisin/kexin type 1 inhibitor antikoerper, PCSK1N antikoerper, Pcsk1n antikoerper

Hintergrund: Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Alias Symbols: Saas
Protein Interaction Partner: STXBP5L,
Protein Size: 260

Molekulargewicht: 28 kDa

Gen-ID: 246333

NCBI Accession: NM_019279, NP_062152

UniProt: Q9QXU9