LRP1 Antikörper (Middle Region)

Produktnummer ABIN2787740

Produktdetails anti-LRP1 Antikörper

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: ATYLSGAQVS TITPTSTRQT TAMDFSYANE TVCWVHVGDS AAQTQLKCAR

Produktmerkmale: This is a rabbit polyclonal antibody against LRP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LRP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 439 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-LRP1 Antikörper (ABIN2787740)

Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: "Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype." in: Journal of lipid research, Vol. 54, Issue 10, pp. 2658-64, (2013) (PubMed).

Gu, Wei, Monnot, Fontanilla, Behl, Farlow, Zheng, Du: "Lead exposure increases levels of ?-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice." in: Neuroscience letters, Vol. 490, Issue 1, pp. 16-20, (2011) (PubMed).

Behl, Zhang, Monnot, Jiang, Zheng: "Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1." in: Toxicology and applied pharmacology, Vol. 240, Issue 2, pp. 245-54, (2009) (PubMed).

Details zu LRP1

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Andere Bezeichnung: LRP1 (LRP1 Produkte)

Synonyme: A2MR antikoerper, APOER antikoerper, APR antikoerper, CD91 antikoerper, IGFBP3R antikoerper, LRP antikoerper, LRP1A antikoerper, TGFBR5 antikoerper, A2mr antikoerper, AI316852 antikoerper, Lrp antikoerper, LRP-1 antikoerper, LDL receptor related protein 1 antikoerper, prolow-density lipoprotein receptor-related protein 1 antikoerper, low density lipoprotein receptor-related protein 1 antikoerper, LRP1 antikoerper, Lrp1 antikoerper, LOC100414789 antikoerper

Hintergrund: Low-density lipoprotein receptor-related protein 1 (.-2-macroglobulin receptor, LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in the extracellular matrix. It is also involved in intracellular signaling and the subcellular translocation of preassembled signaling complexes from the plasma membrane.
Alias Symbols: APR, LRP, A2MR, CD91, APOER, TGFBR5, IGFBP3R
Protein Interaction Partner: UBC, COPS5, APP, RANBP9, SKIL, CHFR, CUBN, FBXO6, ANKS1B, RIC8B, PID1, CC2D1A, MAPRE1, HNRNPDL, MAPK8IP1, SNRNP70, APOE, CACNA1A, USP3, CAV1, MMP14, SHC1, MMP13, SERPINA1, F9, F8, LPL, HSP90B1, SRC, PDGFB, THBS1, SCN3A, PLAUR, PLAT, SERPINE1, MDK, LIPC, L
Protein Size: 439

Molekulargewicht: 48 kDa

Gen-ID: 4035

NCBI Accession: NM_002332

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling