ATG4B Antikörper (N-Term)

Produktnummer ABIN2787433

Produktdetails anti-ATG4B Antikörper

Target: ATG4B (Autophagy related 4B Cysteine Peptidase (ATG4B))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: WGCMLRCGQM IFAQALVCRH LGRDWRWTQR KRQPDSYFSV LNAFIDRKDS

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 85%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ATG4B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATG4B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 393 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATG4B

Target: ATG4B (Autophagy related 4B Cysteine Peptidase (ATG4B))

Andere Bezeichnung: ATG4B (ATG4B Produkte)

Hintergrund: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. ATG4B is a member of the autophagin protein family, it is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: APG4B, AUTL1, MGC1353
Protein Interaction Partner: SUMO2, MAP1LC3B, MAP1LC3A, BAG3, ATG8, YWHAB, GABARAPL1, SQSTM1, UBC, GABARAPL2, ATG10, ATG3, AMBRA1, GABARAP, CAMKK2, ATG12, ULK1, STK3, KRT4, ANXA1, FBXW11, LINC00341,
Protein Size: 393

Molekulargewicht: 44 kDa

Gen-ID: 23192

NCBI Accession: NM_013325, NP_037457

UniProt: Q9Y4P1

Pathways: Autophagie