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NSMCE2 Antikörper (Middle Region)

NSMCE2 Reaktivität: Human, Maus, Kaninchen, Pferd, Meerschweinchen, Rind (Kuh) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2786320
  • Target Alle NSMCE2 Antikörper anzeigen
    NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
    Bindungsspezifität
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 23
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Kaninchen, Pferd, Meerschweinchen, Rind (Kuh)
    Wirt
    • 21
    • 2
    Kaninchen
    Klonalität
    • 23
    Polyklonal
    Konjugat
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NSMCE2 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    KFLALQSKNS DADFQNNEKF VQFKQQLKEL KKQCGLQADR EADGTEGVDE
    Homologie
    Cow: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against NSMCE2. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2
    Top Product
    Discover our top product NSMCE2 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 247 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
    Andere Bezeichnung
    NSMCE2 (NSMCE2 Produkte)
    Synonyme
    1110014D18Rik antikoerper, AI661537 antikoerper, RGD1305156 antikoerper, C8orf36 antikoerper, MMS21 antikoerper, NSE2 antikoerper, ZMIZ7 antikoerper, Non-SMC element 2 antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog antikoerper, Smc5-6 complex non-SMC subunit 2 antikoerper, Nsmce2 antikoerper, NSMCE2 antikoerper, nsmce2.L antikoerper, nse2 antikoerper
    Hintergrund
    NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
    Alias Symbols: C8orf36, FLJ32440, MMS21, NSE2
    Protein Interaction Partner: TXLNA, PAN2, UBC, NSMCE1, SMC6, PDS5A, SMC5, WAPAL, PDS5B, STAG2, SMC3, SMC1A, SUMO1, TSNAX, RAD21, ETV1, SUMO2,
    Protein Size: 247
    Molekulargewicht
    28 kDa
    Gen-ID
    286053
    NCBI Accession
    NM_173685, NP_775956
    UniProt
    Q96MF7
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