DKK2 Antikörper (Middle Region)

Produktnummer ABIN2786024

Produktdetails anti-DKK2 Antikörper

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DKK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NGICIPVTES ILTPHIPALD GTRHRDRNHG HYSNHDLGWQ NLGRPHSKMP

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Dkk2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 259 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DKK2

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Andere Bezeichnung: Dkk2 (DKK2 Produkte)

Synonyme: DKK-2 antikoerper, Dkk4 antikoerper, zgc:171574 antikoerper, dickkopf WNT signaling pathway inhibitor 2 antikoerper, DKK2 antikoerper, Dkk2 antikoerper, dkk2 antikoerper

Hintergrund: Dkk2 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.
Alias Symbols: -
Protein Size: 259

Molekulargewicht: 28 kDa

Gen-ID: 56811

NCBI Accession: NM_020265, NP_064661

UniProt: Q9QYZ8

Pathways: WNT Signalweg