TAB1 Antikörper (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1) (N-Term)

Details for Product anti-TAB1 Antibody No. ABIN2785275, Anbieter: Anmelden zum Anzeigen
Antigen
  • 3'-Tab1
  • MAP3K7IP1
  • 2310012M03Rik
  • Map3k7ip1
  • b2b449Clo
  • TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • TAB1
  • Tab1
Epitop
N-Term
31
10
10
9
9
8
8
6
6
5
5
2
2
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Hund, Meerschweinchen, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
180
78
60
7
6
4
3
3
2
2
1
1
1
1
Wirt
Kaninchen
153
25
2
Klonalität
Polyklonal
Konjugat
Dieser TAB1 Antikörper ist unkonjugiert
9
9
8
6
6
6
3
2
2
2
2
2
2
2
2
2
2
Applikation
Western Blotting (WB)
129
74
27
20
18
15
12
12
9
3
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN979778.
Sequenz MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
Homologie Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against MAP3K7IP1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Plasmids, Primers & others Plasmide, Primers & weitere TAB1 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung MAP3K7IP1 (TAB1 Antibody Abstract)
Hintergrund The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: 3'-Tab1, MGC57664, TAB1, MAP3K7IP1
Protein Interaction Partner: MAGED1, BAG2, MAP3K7, TIRAP, MDM2, SLMAP, NPM1, BIRC3, TRIP6, PPP2R1A, PPP2CB, GRB2, FN1, CDK5RAP3, TAB2, CORO1A, WTAP, MAPK8IP1, UBC, MAPK14, BST2, MAPK12, HSP90AA1, NOTCH1, IKBKB, GRK5, EGFR, STE11, BIRC7, NAIP, XIAP, OGT, TAB3, NR2C2, ARRB2, ARAP1, ACA
Protein Size: 462
Molekulargewicht 50 kDa
Gen-ID 10454
NCBI Accession NM_153497, NP_705717
UniProt Q8IZW2
Pathways TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 462 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (N-Term) antibody (ABIN2785275) WB Suggested Anti-MAP3K7IP1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:...
Allgemeine Veröffentlichungen Neil, Schiemann: "Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression." in: Cancer research, Vol. 68, Issue 5, pp. 1462-70, 2008 (PubMed).

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