PADI2 Antikörper (Middle Region)

Produktnummer ABIN2784886

Produktdetails anti-PADI2 Antikörper

Target: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Hund, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PADI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RGDRWIQDEI EFGYIEAPHK GFPVVLDSPR DGNLKDFPVK ELLGPDFGYV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against PADI2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PADI2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 665 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PADI2

Target: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Andere Bezeichnung: PADI2 (PADI2 Produkte)

Synonyme: PADI2 antikoerper, PAD-H19 antikoerper, PAD2 antikoerper, PDI2 antikoerper, Pdi antikoerper, Pdi2 antikoerper, mKIAA0994 antikoerper, peptidyl arginine deiminase 2 antikoerper, peptidyl arginine deiminase, type II antikoerper, protein-arginine deiminase type-2 antikoerper, peptidyl arginine deiminase, type II S homeolog antikoerper, PADI2 antikoerper, padi2 antikoerper, LOC100357368 antikoerper, padi2.S antikoerper, Padi2 antikoerper

Hintergrund: PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. PADI2 is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: KIAA0994, PAD-H19, PAD2, PDI2
Protein Interaction Partner: UBC,
Protein Size: 665

Molekulargewicht: 75 kDa

Gen-ID: 11240

NCBI Accession: NM_007365, NP_031391

UniProt: Q9Y2J8