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E-cadherin Antikörper (Middle Region)

CDH1 Reaktivität: Human, Maus, Ratte, Schwein, Hund, Kaninchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio) WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2784498
  • Target Alle E-cadherin (CDH1) Antikörper anzeigen
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Bindungsspezifität
    • 17
    • 17
    • 16
    • 16
    • 16
    • 15
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 250
    • 102
    • 86
    • 18
    • 16
    • 15
    • 8
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Schwein, Hund, Kaninchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio)
    Wirt
    • 201
    • 83
    • 8
    • 7
    Kaninchen
    Klonalität
    • 187
    • 111
    • 1
    Polyklonal
    Konjugat
    • 140
    • 36
    • 29
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser E-cadherin Antikörper ist unkonjugiert
    Applikation
    • 206
    • 94
    • 91
    • 68
    • 57
    • 55
    • 39
    • 35
    • 29
    • 27
    • 17
    • 16
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequenz
    QEITSYTAQE PDTFMEQKIT YRIWRDTANW LEINPDTGAI STRAELDRED
    Homologie
    Cow: 93%, Dog: 79%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 85%
    Produktmerkmale
    This is a rabbit polyclonal antibody against CDH1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CDH1
    Top Product
    Discover our top product CDH1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 882 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Andere Bezeichnung
    CDH1 (CDH1 Produkte)
    Synonyme
    Arc-1 antikoerper, CD324 antikoerper, CDHE antikoerper, ECAD antikoerper, LCAM antikoerper, UVO antikoerper, E-cadherin antikoerper, cdh1 antikoerper, si:dz180o5.2 antikoerper, uvo antikoerper, lcam antikoerper, E-Cad antikoerper, XBcad antikoerper, l-cam antikoerper, xcdh1 antikoerper, cdhc-A antikoerper, xb-cad antikoerper, XTCAD-1 antikoerper, c-cadherin antikoerper, cadherin-1 antikoerper, uvomorulin antikoerper, XB-cadherin antikoerper, arc-1 antikoerper, cd324 antikoerper, cdhe antikoerper, ecad antikoerper, AA960649 antikoerper, E-cad antikoerper, Ecad antikoerper, L-CAM antikoerper, Um antikoerper, cadherin 1 antikoerper, si:busm1-180o5.2 antikoerper, cadherin 1, type 1, E-cadherin (epithelial) antikoerper, cadherin 1, type 1 S homeolog antikoerper, CDH1 antikoerper, si:busm1-180o5.2 antikoerper, cdh1 antikoerper, Cdh1 antikoerper, cdh1.S antikoerper
    Hintergrund
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: Arc-1, CD324, CDHE, ECAD, LCAM, UVO
    Protein Interaction Partner: UBC, MDM2, UCHL3, CDC27, PTEN, CTNNB1, PIP5K1C, CTNND1, CBLL1, RNF2, GMNN, LMNA, KRT18, KRT9, KRT8, KRT1, IGHA1, HSPD1, HSP90AA1, HSPA9, HSPA8, HSPA5, GBAS, CTNNA1, CRYAB, CFTR, C1QBP, ACTN4, ACADVL, ANP32B, NIPSNAP1, XRCC5, TGM2, SKP2, SET, RAD17, POLR2E
    Protein Size: 882
    Molekulargewicht
    80 kDa
    Gen-ID
    999
    NCBI Accession
    NM_004360, NP_004351
    UniProt
    P12830
    Pathways
    WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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