NUDT15 Antikörper (N-Term)

Produktnummer ABIN2783521

Produktdetails anti-NUDT15 Antikörper

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUDT15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RKGSFGAGSF QLPGGHLEFG ETWEECAQRE TWEEAGLHLK NVCFASVVNS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against Nudt15. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 170 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NUDT15

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Andere Bezeichnung: Nudt15 (NUDT15 Produkte)

Synonyme: MTH2 antikoerper, RP11-90M2.1 antikoerper, 6530403O17 antikoerper, A730068G11Rik antikoerper, nudix hydrolase 15 antikoerper, nudix (nucleoside diphosphate linked moiety X)-type motif 15 antikoerper, NUDT15 antikoerper, Nudt15 antikoerper

Hintergrund: Nudt15 mediates the hydrolysis of some nucleoside diphosphate derivatives. It can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. Nudt15 may have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
Alias Symbols: 6530403O17, A730068G11Rik, MTH2
Protein Size: 170

Molekulargewicht: 19 kDa

Gen-ID: 214254

NCBI Accession: NM_172527, NP_766115

UniProt: Q8BG93