HADHB Antikörper (C-Term)

Produktnummer ABIN2783232

Produktdetails anti-HADHB Antikörper

Target: HADHB (Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/enoyl-CoA Hydratase (Trifunctional Protein), beta Subunit (HADHB))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Schwein, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HADHB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LLLGPTYATP KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 83%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HADHB. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HADHB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 474 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HADHB Antikörper (ABIN2783232)

Chen, Young, Chatham, Crossman, DellItalia, Shalev: "TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling." in: American journal of physiology. Heart and circulatory physiology, Vol. 311, Issue 1, pp. H64-75, (2016) (PubMed).

Gerin, Clerbaux, Haumont, Lanthier, Das, Burant, Leclercq, MacDougald, Bommer: "Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 33652-61, (2010) (PubMed).

Details zu HADHB

Target: HADHB (Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/enoyl-CoA Hydratase (Trifunctional Protein), beta Subunit (HADHB))

Andere Bezeichnung: HADHB (HADHB Produkte)

Synonyme: ECHB antikoerper, MTPB antikoerper, TP-BETA antikoerper, thiolase antikoerper, fb14g10 antikoerper, wu:fb14g10 antikoerper, zgc:56274 antikoerper, 4930479F15Rik antikoerper, Mtpb antikoerper, Hadhb antikoerper, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta antikoerper, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta S homeolog antikoerper, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit antikoerper, hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit antikoerper, HADHB antikoerper, hadhb.S antikoerper, Hadhb antikoerper, hadhb antikoerper

Hintergrund: HADHB is the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in HADHB gene result in trifunctional protein deficiency. The protein can also bind RNA and decreases the stability of some mRNAs.This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found, however, their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC87480, MSTP029, TP-BETA, ECHB, MTPB
Protein Interaction Partner: HUWE1, TP53, TUBG1, SUMO2, SUMO3, UBC, PARK2, PPP6R1, ADRB2, CSNK2A2, PAN2, ATF2, vpu, TIMM8B, COX17, IQCB1, SUOX, CHCHD4, TUBB1, RPS8, OPA1, HSP90AB1, HADHA, DES, GRK5, FBXO6, CDK2, LEO1, RTF1, TK1, SMN1, PSMA3, GRB7, RCC1, CDKN1A, ANXA7, Edc4, MYC, SQST
Protein Size: 474

Molekulargewicht: 47 kDa

Gen-ID: 3032

NCBI Accession: NM_000183, NP_000174

UniProt: P55084

Pathways: Monocarboxylic Acid Catabolic Process