beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) Antikörper

Details zu Produkt Nr. ABIN2782766, Anbieter: Anmelden zum Anzeigen
Antigen
  • ASP2
  • BACE
  • HSPC104
  • C76936
  • Bace
  • MGC145931
  • bace2
  • MGC68881
  • MGC68482
  • BACE1
  • zgc:77409
  • BACE2
  • beta-secretase 1
  • beta-site APP cleaving enzyme 1
  • beta-site APP-cleaving enzyme 1
  • beta-site APP-cleaving enzyme 2 L homeolog
  • beta-site APP-cleaving enzyme 2 S homeolog
  • beta-site APP-cleaving enzyme 2
  • BACE1
  • Bace1
  • bace1
  • bace2.L
  • bace2.S
  • bace2
  • BACE2
Epitop
N-Term
42
38
20
19
15
12
9
9
6
5
5
5
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Zebrafisch (Danio rerio)
254
162
116
21
12
11
7
6
6
6
6
6
5
3
2
2
1
1
Wirt
Kaninchen
194
70
5
Klonalität
Polyklonal
Konjugat
Unkonjugiert
9
8
6
6
5
5
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
171
99
72
49
42
31
30
26
16
5
3
3
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human BACE1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN973702.
Sequenz GQGYYVEMTV GSPPQTLNIL VDTGSSNFAV GAAPHPFLHR YYQRQLSSTY
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%
Produktmerkmale This is a rabbit polyclonal antibody against BACE1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung BACE1 (BACE Antibody Abstract)
Hintergrund Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein. BACE1, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: ASP2, BACE, FLJ90568, HSPC104, KIAA1149
Protein Interaction Partner: COPS5, BRI3, RANBP9, APP, PCSK9, GGA1, GGA3, GGA2, UBC, FBXO2, CMPK1, ITM2C, KHSRP, PLSCR1, NCSTN, PDIA3, CSNK1D, SELPLG, ATP1B1, PSAP, FURIN, MMP2, LRP1, PSEN1,
Protein Size: 501
Molekulargewicht 51 kDa
Gen-ID 23621
NCBI Accession NM_012104, NP_036236
UniProt P56817
Forschungsgebiet Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 501 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN2782766) WB Suggested Anti-BACE1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
 image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN2782766) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN2782766) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (Image 3)
Allgemeine Veröffentlichungen Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: "Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production." in: Molecular and cellular biology, Vol. 28, Issue 11, pp. 3663-71, 2008 (PubMed).

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