ATP6V0A1 Antikörper (N-Term)

Produktnummer ABIN2782670

Produktdetails anti-ATP6V0A1 Antikörper

Target: ATP6V0A1 (ATPase, H+ Transporting, Lysosomal V0 Subunit A1 (ATP6V0A1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Hund, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP6V0A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RDLNPDVNVF QRKFVNEVRR CEEMDRKLRF VEKEIRKANI PIMDTGENPE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ATP6V0A1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V0A1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 831 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ATP6V0A1 Antikörper (ABIN2782670)

Leiva-Rodríguez, Romeo-Guitart, Marmolejo-Martínez-Artesero, Herrando-Grabulosa, Bosch, Forés, Casas: "ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-trafficking alterations in axotomized motoneurons." in: Cell death & disease, Vol. 9, Issue 6, pp. 626, (2019) (PubMed).

Antonacopoulou, Grivas, Skarlas, Kalofonos, Scopa, Kalofonos: "POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?" in: Anticancer research, Vol. 28, Issue 2B, pp. 1221-7, (2008) (PubMed).

Details zu ATP6V0A1

Target: ATP6V0A1 (ATPase, H+ Transporting, Lysosomal V0 Subunit A1 (ATP6V0A1))

Andere Bezeichnung: ATP6V0A1 (ATP6V0A1 Produkte)

Synonyme: ATP6N1 antikoerper, ATP6N1A antikoerper, Stv1 antikoerper, VPP1 antikoerper, Vph1 antikoerper, a1 antikoerper, AA959968 antikoerper, ATP6a1 antikoerper, Atp6n1 antikoerper, Atp6n1a antikoerper, Atpv0a1 antikoerper, Vpp-1 antikoerper, Vpp1 antikoerper, A1 antikoerper, wu:fj37e01 antikoerper, zgc:112214 antikoerper, atp6v0a1 antikoerper, wu:fc25b09 antikoerper, zgc:76965 antikoerper, ATPase H+ transporting V0 subunit a1 antikoerper, ATPase, H+ transporting, lysosomal V0 subunit A1 antikoerper, si:ch73-173p19.2 antikoerper, ATPase, H+ transporting, lysosomal V0 subunit a1 L homeolog antikoerper, ATPase, H+ transporting, lysosomal V0 subunit a1b antikoerper, ATPase, H+ transporting, lysosomal V0 subunit a1a antikoerper, ATP6V0A1 antikoerper, Atp6v0a1 antikoerper, si:ch73-173p19.2 antikoerper, atp6v0a1.L antikoerper, atp6v0a1b antikoerper, atp6v0a1a antikoerper

Hintergrund: ATP6V0A1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. ATP6V0A1 is one of three A subunit proteins and it is associated with clathrin-coated vesicles. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. The occurrence of splice variants encoding different protein products has been reported, but the full-length natures of these transcripts have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ATP6N1, ATP6N1A, DKFZp781J1951, Stv1, VPP1, Vph1, a1
Protein Interaction Partner: SEH1L, ZNF267, SNX4, UBC, CLIC1, MARCKSL1, MRPL44, SLC30A5, MRPL50, PTRH2, ATP6V1D, MRPL46, SCFD1, VAMP2, SRSF3, RPS18, RPS15, SLC25A3, PA2G4, NONO, ATP6V1E1, ATP6V1B1,
Protein Size: 831

Molekulargewicht: 96 kDa

Gen-ID: 535

NCBI Accession: NM_005177, NP_005168

UniProt: Q93050

Pathways: Transition Metal Ion Homeostasis, Proton Transport