MTHFD1 Antikörper (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase) (Middle Region)

Details for Product anti-MTHFD1 Antibody No. ABIN2782515, Anbieter: Anmelden zum Anzeigen
Antigen
  • GB13160
  • Tb07.27M11.970
  • MTHFC
  • MTHFD
  • cb325
  • fc29f07
  • mthfd1
  • wu:fc29f07
  • zgc:55597
  • Dcs
  • E430024A07Rik
  • Mthfd
  • C-1-tetrahydrofolate synthase, cytoplasmic
  • putative C-1-tetrahydrofolate synthase, cytoplasmic
  • formate--tetrahydrofolate ligase
  • putative C-1-tetrahydrofolate synthase,cytoplasmic
  • c-1-tetrahydrofolate synthase, cytoplasmic
  • methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
  • C-1-tetrahydrofolate synthase, cytoplasmic pseudogene
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase L homeolog
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
  • LOC550749
  • Tc00.1047053509509.20
  • Tc00.1047053511741.50
  • Tc00.1047053511517.60
  • Tc00.1047053508207.240
  • Tb927.7.1600
  • LINJ_26_0310
  • FTHS
  • LBRM_26_0350
  • LMJF_26_0320
  • Tsp_00651
  • MTHFD1
  • mthfd1l
  • mthfd1
  • LOC589933
  • LOC705985
  • LOC100634307
  • Mthfd1
  • mthfd1.L
  • mthfd1b
Epitop
Middle Region
8
7
5
3
3
2
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus), Yeast (Saccharomyces cerevisiae), Zebrafisch (Danio rerio)
43
14
12
4
3
3
3
3
2
2
2
1
1
Wirt
Kaninchen
21
20
2
Klonalität
Polyklonal
Konjugat
Dieser MTHFD1 Antikörper ist unkonjugiert
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
42
17
14
10
7
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human MTHFD1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN980337.
Sequenz CMAKTHLSLS HNPEQKGVPT GFILPIRDIR ASVGAGFLYP LVGTMSTMPG
Homologie Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 79%
Produktmerkmale This is a rabbit polyclonal antibody against MTHFD1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung MTHFD1 (MTHFD1 Antibody Abstract)
Hintergrund MTHFD1 possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MTHFC, MTHFD
Protein Interaction Partner: UBC, FUS, SUMO2, SUMO3, NEDD8, MDM2, RPA3, RPA2, RPA1, RNF2, RPS21, MAT2A, UBQLN1, FBXO6, UBD, ADRB2, CD81, VCAM1, HSP90AA1, HSP90AB1, PRKCDBP, SFXN1, TMEM165, IARS2, SARS2, SF3B3, FAF2, PPT2, SNRNP70, RPL32, MRPL23, ALDH18A1, PRPH, PC, ICT1, GAA, ACSL3,
Protein Size: 935
Molekulargewicht 101 kDa
Gen-ID 4522
NCBI Accession NM_005956, NP_005947
UniProt P11586
Forschungsgebiet Metabolism, Amino Acids
Pathways Methionine Biosynthetic Process
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 935 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) (Middle Region) antibody (ABIN2782515) anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) (Middle Region) antibody
Allgemeine Veröffentlichungen Palmieri, Masiero, Martinelli, Scapoli, Pezzetti, Caramelli, Guidotti, Carinci: "The MTHFD1 gene is not involved in cleft lip with or without palate onset among the Italian population." in: Annals of human genetics, Vol. 72, Issue Pt 3, pp. 297-9, 2008 (PubMed).

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