SLC11A1 Antikörper (Middle Region)

Produktnummer ABIN2781544

Produktdetails anti-SLC11A1 Antikörper

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Rind (Kuh), Meerschweinchen, Kaninchen, Ziege, Pferd, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC11A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA IIMPHNIYLH

Homologie: Cow: 86%, Goat: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Rabbit: 93%, Rat: 86%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against SLC11A1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SLC11A1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SLC11A1

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Andere Bezeichnung: SLC11A1 (SLC11A1 Produkte)

Synonyme: SLC11A1 antikoerper, NRAMP1 antikoerper, LSH antikoerper, NRAMP antikoerper, Bcg antikoerper, Itg antikoerper, Lsh antikoerper, Nramp1 antikoerper, Ity antikoerper, Nramp antikoerper, ity antikoerper, BCG antikoerper, solute carrier family 11 member 1 L homeolog antikoerper, solute carrier family 11 member 1 antikoerper, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 antikoerper, slc11a1.L antikoerper, SLC11A1 antikoerper, Slc11a1 antikoerper

Hintergrund: SLC11A1 is a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. It controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Alias Symbols: LSH, NRAMP, NRAMP1
Protein Size: 550

Molekulargewicht: 60 kDa

Gen-ID: 6556

NCBI Accession: NM_000578, NP_000569

UniProt: P49279

Pathways: Transition Metal Ion Homeostasis, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus