ABCC5 Antikörper (C-Term)

Produktnummer ABIN2781499

Produktdetails anti-ABCC5 Antikörper

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCC5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ABCC5. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human ABCC5

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ABCC5

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Andere Bezeichnung: ABCC5 (ABCC5 Produkte)

Synonyme: ABC33 antikoerper, EST277145 antikoerper, MOAT-C antikoerper, MOATC antikoerper, MRP5 antikoerper, SMRP antikoerper, pABC11 antikoerper, 2900011L11Rik antikoerper, AI132311 antikoerper, Abcc5a antikoerper, Abcc5b antikoerper, Mrp5 antikoerper, abc33 antikoerper, abcc5 antikoerper, moat-c antikoerper, moatc antikoerper, mrp5 antikoerper, pabc11 antikoerper, smrp antikoerper, ATP binding cassette subfamily C member 5 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 5 antikoerper, ATP binding cassette subfamily C member 5 L homeolog antikoerper, ABCC5 antikoerper, Abcc5 antikoerper, abcc5.L antikoerper

Hintergrund: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
Alias Symbols: MRP5, SMRP, ABC33, MOATC, MOAT-C, pABC11, EST277145
Protein Size: 231

Molekulargewicht: 25 kDa

Gen-ID: 10057

NCBI Accession: NM_001023587, NP_001018881

UniProt: O15440

Pathways: Glycosaminoglycan Metabolic Process