TAP1 Antikörper (Middle Region)

Produktnummer ABIN2781498

Produktdetails anti-TAP1 Antikörper

Target: TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LVTFVLYQMQ FTQAVEVLLS IYPRVQKAVG SSEKIFEYLD RTPRCPPSGL

Homologie: Cow: 92%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%, Zebrafish: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against TAP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TAP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 808 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TAP1

Target: TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))

Andere Bezeichnung: TAP1 (TAP1 Produkte)

Synonyme: ABC17 antikoerper, ABCB2 antikoerper, APT1 antikoerper, D6S114E antikoerper, PSF-1 antikoerper, PSF1 antikoerper, RING4 antikoerper, TAP1*0102N antikoerper, TAP1N antikoerper, abc17 antikoerper, abcb2 antikoerper, apt1 antikoerper, psf1 antikoerper, ring4 antikoerper, tap1a antikoerper, tap1n antikoerper, Abcb2 antikoerper, Ham-1 antikoerper, Ham1 antikoerper, MTP1 antikoerper, TAP antikoerper, Tap-1 antikoerper, Y3 antikoerper, Cim antikoerper, transporter 1, ATP binding cassette subfamily B member antikoerper, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog antikoerper, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) antikoerper, TAP1 antikoerper, tap1.L antikoerper, Tap1 antikoerper

Hintergrund: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). TAP1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. TAP1 is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC17, ABCB2, APT1, D6S114E, FLJ26666, FLJ41500, PSF1, RING4, TAP1*0102N, TAP1N, PSF-1
Protein Interaction Partner: UBC, MUL1, TDP2, SFXN1, GADD45GIP1, MRPL40, MCAT, SRSF3, SDHA, ABCD3, CYC1, PSMB8, TAPBP, TAP2, HLA-A, PDIA3, CALR, B2M, PDIA2, KRTAP4-12, MDFI, PSMB5, HLA-F, HLA-G, ESR1, COPG1, COPB1,
Protein Size: 808

Molekulargewicht: 87 kDa

Gen-ID: 6890

NCBI Accession: NM_000593, NP_000584

UniProt: Q03518

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process