NR2E3 Antikörper (N-Term)

Produktnummer ABIN2780915

Produktdetails anti-NR2E3 Antikörper

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR2E3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: METRPTALMS STVAAAAPAA GAASRKESPG RWGLGEDPTG VSPSLQCRVC

Homologie: Cow: 86%, Human: 100%, Mouse: 93%, Pig: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NR2E3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR2E3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 410 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NR2E3 Antikörper (ABIN2780915)

Hayashi, Gekka, Goto-Omoto, Takeuchi, Kubo, Kitahara: "Novel NR2E3 mutations (R104Q, R334G) associated with a mild form of enhanced S-cone syndrome demonstrate compound heterozygosity." in: Ophthalmology, Vol. 112, Issue 12, pp. 2115, (2005) (PubMed).

Details zu NR2E3

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Andere Bezeichnung: NR2E3 (NR2E3 Produkte)

Synonyme: ESCS antikoerper, PNR antikoerper, RNR antikoerper, RP37 antikoerper, rd7 antikoerper, LOC100228348 antikoerper, A930035N01Rik antikoerper, wu:fj55b07 antikoerper, zgc:103631 antikoerper, nuclear receptor subfamily 2 group E member 3 antikoerper, nuclear receptor subfamily 2, group E, member 3 antikoerper, NR2E3 antikoerper, Nr2e3 antikoerper, nr2e3 antikoerper

Hintergrund: NR2E3 is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. NR2E3 is a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome.This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: PNR, RNR, rd7, ESCS, RP37
Protein Interaction Partner: BCL11A, SIN3A, DHX30, TBL3, MYBBP1A, NCOR1, HDAC3, RBL1, RBBP7, RBBP4, HDAC1, CDK9, VDR, DEDD2, RBFOX2, IRF9, ZNF232, SNAPC1, PPARG, HOXC13, NR3C1, ELAVL2, POLR3D, RARA, NR1D1, CRX, RXRB, RXRA,
Protein Size: 410

Molekulargewicht: 45 kDa

Gen-ID: 10002

NCBI Accession: NM_014249, NP_055064

UniProt: Q9Y5X4

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway