NR2C1 Antikörper (N-Term)

Produktnummer ABIN2780498

Produktdetails anti-NR2C1 Antikörper

Target: NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen, Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR2C1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: ATIEEIAHQI IEQQMGEIVT EQQTGQKIQI VTALDHNTQG KQFILTNHDG

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NR2C1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR2C1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 467 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NR2C1

Target: NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))

Andere Bezeichnung: NR2C1 (NR2C1 Produkte)

Synonyme: TR2 antikoerper, NR2C1 antikoerper, dor2 antikoerper, tr2-11 antikoerper, xDOR2 antikoerper, DKFZp468M0512 antikoerper, si:dkey-183c16.2 antikoerper, zgc:110672 antikoerper, 4831444H07Rik antikoerper, 80.3 antikoerper, Eenr antikoerper, Tr2-11 antikoerper, Tr2 antikoerper, Psg4 antikoerper, TR2-11 antikoerper, PSG9 antikoerper, nr2c1 antikoerper, nuclear receptor subfamily 2 group C member 1 antikoerper, nuclear receptor subfamily 2 group C member 1 S homeolog antikoerper, nuclear receptor subfamily 2, group C, member 1 antikoerper, pregnancy specific beta-1-glycoprotein 4 antikoerper, nuclear receptor subfamily 2 group C member 1 L homeolog antikoerper, NR2C1 antikoerper, nr2c1.S antikoerper, nr2c1 antikoerper, Nr2c1 antikoerper, PSG4 antikoerper, nr2c1.L antikoerper

Hintergrund: The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Alias Symbols: TR2, TR2-11
Protein Interaction Partner: PSPC1, MBD3, SIN3A, RCOR1, KDM1A, POLD3, TRIM28, RBM39, MTA2, MTA1, HDAC3, NR2C2, SMARCA4, SFPQ, RBBP7, RBBP4, NONO, HDAC2, HDAC1, HCFC1, DNMT1, CHD4, NUDT3, UBC, PML, HDAC4, NRIP1, AR, ESR1,
Protein Size: 467

Molekulargewicht: 51 kDa

Gen-ID: 7181

NCBI Accession: NM_001032287, NP_001027458

UniProt: Q15626

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway