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RUNX1 Antikörper (N-Term)
RUNX1
Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2780299
Produktdetails anti-RUNX1 Antikörper
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Target
Alle RUNX1 Antikörper anzeigen
RUNX1
(Runt-Related Transcription Factor 1 (RUNX1))
Bindungsspezifität
Alle Epitope für RUNX1 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für RUNX1 Antikörper
Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen
Wirt
Alle Wirte für RUNX1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für RUNX1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für RUNX1 Antikörper
Dieser RUNX1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für RUNX1 Antikörper
Western Blotting (WB)
Sequenz
KMSEALPLGA PDGGPALASK LRSGDRSMVE VLADHPGELV RTDSPNFLCS
Homologie
Cow: 79%, Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 93%
Produktmerkmale
This is a rabbit polyclonal antibody against Runx1. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Runx1
Top Product
Discover our top product RUNX1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu RUNX1
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Target
RUNX1
(Runt-Related Transcription Factor 1 (RUNX1))
Andere Bezeichnung
Runx1 (RUNX1 Produkte )
Synonyme
RUNX1 antikoerper, runx1 antikoerper, AI462102 antikoerper, AML1 antikoerper, Cbfa2 antikoerper, Pebp2a2 antikoerper, Pebpa2b antikoerper, AML1-EVI-1 antikoerper, AMLCR1 antikoerper, CBFA2 antikoerper, EVI-1 antikoerper, PEBP2aB antikoerper, runxa antikoerper, Runx-1 antikoerper, XAML antikoerper, Xaml1 antikoerper, aml antikoerper, aml-1 antikoerper, aml1 antikoerper, aml1-evi-1 antikoerper, amlcr1 antikoerper, cbfa2 antikoerper, evi-1 antikoerper, pebp2ab antikoerper, Aml1 antikoerper, uncharacterized LOC473981 antikoerper, runt-related transcription factor antikoerper, runt related transcription factor 1 antikoerper, runt-related transcription factor 1 antikoerper, runt related transcription factor 1 L homeolog antikoerper, LOC473981 antikoerper, runt antikoerper, Runx1 antikoerper, RUNX1 antikoerper, runx1 antikoerper, runx1.L antikoerper
Hintergrund
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation . Alias Symbols: AI462102, AML1, Cbfa2, Pebp2a2, Pebpa2b Protein Interaction Partner: Kat6a, Ubc, Cbfb, Foxp3, Rbbp4, Gata1, Fli1, Phc1, Cdk6, Cbx3, Bmi1, Pml, Mbd3, Smad2, Prmt1, Hdac2, Hcfc1, Gata2, Hdac1, Wdr5, Mta1, Smarcd1, Pcgf5, Smarcc2, Pold3, Smarce1, Set, Mta2, Ash2l, Tal1, Smarcc1, Smarcb1, Smarca4, Sin3a, Rnf2, Ring1, Cbfa2t3, Protein Size: 387
Molekulargewicht
42 kDa
Gen-ID
12394
NCBI Accession
NM_009821 , NP_033951
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