NR1I3 Antikörper (Middle Region)

Produktnummer ABIN2780298

Produktdetails anti-NR1I3 Antikörper

Target: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Bindungsspezifität: Middle Region

Reaktivität: Maus, Ratte, Hund, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1I3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KELVQILLGA HTRHVGPLFD QFVQFKPPAY LFMHHRPFQP RGPVLPLLTH

Homologie: Cow: 85%, Dog: 86%, Guinea Pig: 79%, Mouse: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NR1I3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse NR1I3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 358 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NR1I3

Target: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Andere Bezeichnung: NR1I3 (NR1I3 Produkte)

Synonyme: AA209988 antikoerper, AI551208 antikoerper, CAR antikoerper, CAR-beta antikoerper, Care2 antikoerper, ESTM32 antikoerper, MB67 antikoerper, CAR1 antikoerper, CXR antikoerper, nuclear receptor subfamily 1 group I member 3 antikoerper, nuclear receptor subfamily 1, group I, member 3 antikoerper, NR1I3 antikoerper, Nr1i3 antikoerper

Hintergrund: NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses.
Alias Symbols: CAR, MB67, Care2, ESTM32, AA209988, AI551208, CAR-beta
Protein Interaction Partner: NCOR2, Ppp2r1a, Ppp2ca, Hsp90ab1, Psmc4, NR0B2, Ncoa1, Ncor1, Rxrg, NCOA6,
Protein Size: 358

Molekulargewicht: 39 kDa

Gen-ID: 12355

NCBI Accession: NM_009803, NP_033933

UniProt: O35627

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway