TAB2 Antikörper (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2) (N-Term)

Details for Product anti-TAB2 Antibody No. ABIN2779619, Anbieter: Anmelden zum Anzeigen
Antigen
  • CHTD2
  • MAP3K7IP2
  • 1110030N06Rik
  • A530078N03Rik
  • Map3k7ip2
  • mKIAA0733
  • map3k7ip2
  • zgc:77446
  • TGF-beta activated kinase 1/MAP3K7 binding protein 2
  • TAB2
  • Tab2
  • tab2
Epitop
N-Term
9
5
5
5
3
2
2
2
2
2
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
59
16
12
6
5
4
4
3
3
2
2
1
1
1
Wirt
Kaninchen
32
19
10
Klonalität
Polyklonal
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
37
23
16
13
12
6
5
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP2
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN979779.
Sequenz QKFPEVPEVV VSRCMLQNNN NLDACCAVLS QESTRYLYGE GDLNFSDDSG
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against MAP3K7IP2. It was validated on Western Blot and immunohistochemistry.
Reinigung Affinity Purified
Andere Bezeichnung MAP3K7IP2 (TAB2 Antibody Abstract)
Hintergrund MAP3K7IP2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of NF.:B and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serving as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF.:B (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Alias Symbols: CHTD2, MAP3K7IP2
Protein Interaction Partner: UBC, PIAS3, UBE2I, TRAF6, SUMO2, IRAK1, MAP3K7, TRIM38, SIK1, SIK3, TRIM22, NPM1, CST9L, SLC19A3, env, TAB1, NUMBL, IKBKG, FOSL1, ZBTB16, YWHAZ, VIM, TGM2, PPP2CB, IKBKB, GTF2I, FN1, HSP90AA1, BST2, MALT1, WDR34, APP, ESR1, MAP3K8, AR, TRIM5, TBL1XR1, MBD
Protein Size: 693
Molekulargewicht 76 kDa
Gen-ID 23118
NCBI Accession NM_015093, NP_055908
UniProt Q9NYJ8
Pathways T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 693 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN2779619) WB Suggested Anti-MAP3K7IP2 Antibody Titration: 0.2-1 ug/ml
Positive Con...
Immunohistochemistry (IHC) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN2779619) anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN2779619) anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (Image 3)
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN2779619) WB Suggested Anti-MAP3K7IP2
Antibody Titration: 0.2-1 µg/mL
Positive Co...
Produkt verwendet in: Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, 2010 (PubMed).

Allgemeine Veröffentlichungen Kanayama, Seth, Sun, Ea, Hong, Shaito, Chiu, Deng, Chen: "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains." in: Molecular cell, Vol. 15, Issue 4, pp. 535-48, 2004 (PubMed).

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