TLE2 Antikörper (N-Term)

Produktnummer ABIN2779582

Produktdetails anti-TLE2 Antikörper

Target: TLE2 (Transducin-Like Enhancer Protein 2 (TLE2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VEEERPSGPG GGGKQRADEK EPSGPYESDE DKSDYNLVVD EDQPSEPPSP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TLE2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TLE2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 743 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TLE2

Target: TLE2 (Transducin-Like Enhancer Protein 2 (TLE2))

Andere Bezeichnung: TLE2 (TLE2 Produkte)

Synonyme: TLE2 antikoerper, ESG antikoerper, ESG2 antikoerper, GRG2 antikoerper, Grg2 antikoerper, mKIAA4188 antikoerper, transducin like enhancer of split 2 antikoerper, transducin-like enhancer of split 2 antikoerper, TLE2 antikoerper, Tle2 antikoerper

Hintergrund: TLE2 belongs to the WD repeat Groucho/TLE family. It contains 6 WD repeats. TLE2 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
Alias Symbols: ESG, ESG2, FLJ41188, GRG2
Protein Interaction Partner: UBC, SUMO1, ORF50, LEF1, BARHL1, TLX3, VENTX, CUL4A, CUL4B, PAX9, MSX2, MSX1, FOXA3, EMX2, PRDM1, H3F3B, TLE1, UTY, HMGB1, RUNX1, TLE2, HES1,
Protein Size: 743

Molekulargewicht: 80 kDa

Gen-ID: 7089

NCBI Accession: NM_003260, NP_003251

UniProt: Q04725

Pathways: WNT Signalweg