ELF3 Antikörper (Middle Region)

Produktnummer ABIN2779520

Produktdetails anti-ELF3 Antikörper

Target: ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PGSCGAGAPS PGSSDVSTAG TGASRSSHSS DSGGSDVDLD PTDGKLFPSD

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ELF3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ELF3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 371 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ELF3

Target: ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))

Andere Bezeichnung: ELF3 (ELF3 Produkte)

Synonyme: ert antikoerper, esx antikoerper, epr-1 antikoerper, ese-1 antikoerper, ESE-1 antikoerper, ESX antikoerper, jen antikoerper, EPR-1 antikoerper, ERT antikoerper, E74 like ETS transcription factor 3 antikoerper, E74-like factor 3 antikoerper, elf3 antikoerper, Elf3 antikoerper, ELF3 antikoerper

Hintergrund: ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Alias Symbols: ERT, ESX, EPR-1, ESE-1
Protein Interaction Partner: MED23, XRCC5, RPL6, XRCC6, EP300, CBR3, Jun, MYC, BTRC, UBC, PAK1, TAF9, SUMO2, TBP, EPS15, CREBBP, NFKB1, EGFR, ERBB2, EHF, GANAB, ISG15, TARS, P4HB, KRT82, KRT31, JAK1, EEF1D, DDX3X, CALR, ATIC,
Protein Size: 371

Molekulargewicht: 41 kDa

Gen-ID: 1999

NCBI Accession: NM_004433, NP_004424

UniProt: P78545