ASCL2 Antikörper (Middle Region)

Produktnummer ABIN2779425

Produktdetails anti-ASCL2 Antikörper

Target: ASCL2 (Achaete-Scute Complex Homolog 2 (ASCL2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASCL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 100%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against ASCL2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ASCL2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 193 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ASCL2 Antikörper (ABIN2779425)

Schwitalla, Fingerle, Cammareri, Nebelsiek, Göktuna, Ziegler, Canli, Heijmans, Huels, Moreaux, Rupec, Gerhard, Schmid, Barker, Clevers, Lang, Neumann, Kirchner, Taketo, van den Brink, Sansom, Arkan et al.: "Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. ..." in: Cell, Vol. 152, Issue 1-2, pp. 25-38, (2013) (PubMed).

Details zu ASCL2

Target: ASCL2 (Achaete-Scute Complex Homolog 2 (ASCL2))

Andere Bezeichnung: ASCL2 (ASCL2 Produkte)

Synonyme: ASH2 antikoerper, HASH2 antikoerper, MASH2 antikoerper, bHLHa45 antikoerper, ASCL2 antikoerper, 2410083I15Rik antikoerper, Mash2 antikoerper, achaete-scute family bHLH transcription factor 2 antikoerper, ASCL2 antikoerper, Ascl2 antikoerper

Hintergrund: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1649 BC028140.1 1-1649 1650-1864 BC057801.1 1286-1500
Alias Symbols: ASH2, HASH2, MASH2, bHLHa45
Protein Interaction Partner: EP300, APEX1, CALM3, CALM1, HCFC1, TUBB, KMT2C, NCOA6, TUBA4A, RBBP5,
Protein Size: 193

Molekulargewicht: 20 kDa

Gen-ID: 430

NCBI Accession: NM_005170, NP_005161

UniProt: Q99929

Pathways: Stem Cell Maintenance