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EYA4 Antikörper (N-Term)

EYA4 Reaktivität: Human, Maus, Kaninchen, Meerschweinchen, Hund, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2778551
  • Target Alle EYA4 Antikörper anzeigen
    EYA4 (Eyes Absent Homolog 4 (EYA4))
    Bindungsspezifität
    • 15
    • 14
    • 8
    • 5
    • 3
    • 3
    • 2
    N-Term
    Reaktivität
    • 44
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Kaninchen, Meerschweinchen, Hund, Zebrafisch (Danio rerio)
    Wirt
    • 43
    • 1
    Kaninchen
    Klonalität
    • 44
    Polyklonal
    Konjugat
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EYA4 Antikörper ist unkonjugiert
    Applikation
    • 22
    • 21
    • 17
    • 14
    • 13
    • 13
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS
    Homologie
    Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 85%
    Produktmerkmale
    This is a rabbit polyclonal antibody against Eya4. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of Eya4
    Top Product
    Discover our top product EYA4 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 616 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    EYA4 (Eyes Absent Homolog 4 (EYA4))
    Andere Bezeichnung
    Eya4 (EYA4 Produkte)
    Synonyme
    B130023L16Rik antikoerper, CMD1J antikoerper, DFNA10 antikoerper, EYA transcriptional coactivator and phosphatase 4 antikoerper, Eya4 antikoerper, EYA4 antikoerper
    Hintergrund
    Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye.
    Alias Symbols: B130023L16Rik
    Protein Interaction Partner: Six1, Six2, Eya4,
    Protein Size: 616
    Molekulargewicht
    67 kDa
    Gen-ID
    14051
    NCBI Accession
    NM_010167, NP_034297
    UniProt
    Q9Z191
    Pathways
    Sensory Perception of Sound
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