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PSMC3 Antikörper (Middle Region)

PSMC3 Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Rind (Kuh), Kaninchen, Pferd, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2777668
  • Target Alle PSMC3 Antikörper anzeigen
    PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
    Bindungsspezifität
    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 60
    • 40
    • 26
    • 20
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Rind (Kuh), Kaninchen, Pferd, Meerschweinchen
    Wirt
    • 53
    • 7
    Kaninchen
    Klonalität
    • 55
    • 5
    Polyklonal
    Konjugat
    • 35
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PSMC3 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 16
    • 15
    • 13
    • 13
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    TKRFDSEKAG DREVQRTMLE LLNQLDGFQP NTQVKVIAAT NRVDILD
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PSMC3. It was validated on Western Blot and immunohistochemistry.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PSMC3
    Top Product
    Discover our top product PSMC3 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 439 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Thompson, Harris, Brody: "Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." in: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).

  • Target
    PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
    Andere Bezeichnung
    PSMC3 (PSMC3 Produkte)
    Synonyme
    TBP1 antikoerper, TBP-1 antikoerper, wu:fb39a02 antikoerper, zgc:86713 antikoerper, psmc3 antikoerper, MGC89608 antikoerper, PSMC3 antikoerper, NV15940 antikoerper, 23.m06430 antikoerper, DDBDRAFT_0186002 antikoerper, DDBDRAFT_0232967 antikoerper, DDB_0186002 antikoerper, DDB_0232967 antikoerper, psmc3-b antikoerper, tbp10 antikoerper, psmc3-a antikoerper, proteasome 26S subunit, ATPase 3 antikoerper, proteasome (prosome, macropain) 26S subunit, ATPase 3 antikoerper, 26S protease regulatory subunit 6A antikoerper, 26S protease regulatory subunit 6a antikoerper, 26S protease regulatory subunit 6A-B antikoerper, 26S protease regulatory subunit 6A, putative antikoerper, proteasome 26S subunit, ATPase 3 S homeolog antikoerper, nth-like DNA glycosylase 1 S homeolog antikoerper, PSMC3 antikoerper, Psmc3 antikoerper, HCAG_00069 antikoerper, GL50803_4365 antikoerper, EDI_316920 antikoerper, CpipJ_CPIJ006888 antikoerper, CpipJ_CPIJ006889 antikoerper, CpipJ_CPIJ010864 antikoerper, prs6a antikoerper, psmc3 antikoerper, LOC100115023 antikoerper, BBOV_IV004580 antikoerper, CGB_M2140W antikoerper, psmC3 antikoerper, LOC100637883 antikoerper, psmc3.S antikoerper, nthl1.S antikoerper
    Hintergrund
    PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9
    Alias Symbols: TBP1
    Protein Interaction Partner: AMOTL2, UBC, PSMD9, PSMC6, PSMC3, KDM1A, HUWE1, SUMO2, PSMD14, MDM2, ASB11, UCHL5, PSMD3, PSMD2, PSMD1, PSMC2, PSMC1, ADRM1, JKAMP, FBXO6, PARK2, BAG3, GADD45A, NOS2, MYC, PSMD13, PSMC4, PSMA8, UBFD1, ECD, STIP1, RANBP9, PSMD6, ZFYVE16, USP14, RUVBL1, PSM
    Protein Size: 439
    Molekulargewicht
    45 kDa
    Gen-ID
    5702
    NCBI Accession
    NM_002804, NP_002795
    UniProt
    Q6IBS1
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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