PSMC3 Antikörper (Middle Region)
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- Target Alle PSMC3 Antikörper anzeigen
- PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Rind (Kuh), Kaninchen, Pferd, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PSMC3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- TKRFDSEKAG DREVQRTMLE LLNQLDGFQP NTQVKVIAAT NRVDILD
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PSMC3. It was validated on Western Blot and immunohistochemistry.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PSMC3
- Top Product
- Discover our top product PSMC3 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 439 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." in: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).
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Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." in: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).
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- Target
- PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
- Andere Bezeichnung
- PSMC3 (PSMC3 Produkte)
- Synonyme
- TBP1 antikoerper, TBP-1 antikoerper, wu:fb39a02 antikoerper, zgc:86713 antikoerper, psmc3 antikoerper, MGC89608 antikoerper, PSMC3 antikoerper, NV15940 antikoerper, 23.m06430 antikoerper, DDBDRAFT_0186002 antikoerper, DDBDRAFT_0232967 antikoerper, DDB_0186002 antikoerper, DDB_0232967 antikoerper, psmc3-b antikoerper, tbp10 antikoerper, psmc3-a antikoerper, proteasome 26S subunit, ATPase 3 antikoerper, proteasome (prosome, macropain) 26S subunit, ATPase 3 antikoerper, 26S protease regulatory subunit 6A antikoerper, 26S protease regulatory subunit 6a antikoerper, 26S protease regulatory subunit 6A-B antikoerper, 26S protease regulatory subunit 6A, putative antikoerper, proteasome 26S subunit, ATPase 3 S homeolog antikoerper, nth-like DNA glycosylase 1 S homeolog antikoerper, PSMC3 antikoerper, Psmc3 antikoerper, HCAG_00069 antikoerper, GL50803_4365 antikoerper, EDI_316920 antikoerper, CpipJ_CPIJ006888 antikoerper, CpipJ_CPIJ006889 antikoerper, CpipJ_CPIJ010864 antikoerper, prs6a antikoerper, psmc3 antikoerper, LOC100115023 antikoerper, BBOV_IV004580 antikoerper, CGB_M2140W antikoerper, psmC3 antikoerper, LOC100637883 antikoerper, psmc3.S antikoerper, nthl1.S antikoerper
- Hintergrund
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PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9
Alias Symbols: TBP1
Protein Interaction Partner: AMOTL2, UBC, PSMD9, PSMC6, PSMC3, KDM1A, HUWE1, SUMO2, PSMD14, MDM2, ASB11, UCHL5, PSMD3, PSMD2, PSMD1, PSMC2, PSMC1, ADRM1, JKAMP, FBXO6, PARK2, BAG3, GADD45A, NOS2, MYC, PSMD13, PSMC4, PSMA8, UBFD1, ECD, STIP1, RANBP9, PSMD6, ZFYVE16, USP14, RUVBL1, PSM
Protein Size: 439 - Molekulargewicht
- 45 kDa
- Gen-ID
- 5702
- NCBI Accession
- NM_002804, NP_002795
- UniProt
- Q6IBS1
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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