CYP3A7 Antikörper (Middle Region)

Produktnummer ABIN2776998

Produktdetails anti-CYP3A7 Antikörper

Target: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP3A7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI

Homologie: Cow: 77%, Dog: 75%, Guinea Pig: 83%, Human: 100%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against CYP3A7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CYP3A7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 503 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CYP3A7 Antikörper (ABIN2776998)

Van Peer, Verbueken, Saad, Casteleyn, Van Ginneken, Van Cruchten: "Ontogeny of CYP3A and P-glycoprotein in the liver and the small intestine of the Göttingen minipig: an immunohistochemical evaluation." in: Basic & clinical pharmacology & toxicology, Vol. 114, Issue 5, pp. 387-94, (2014) (PubMed).

Details zu CYP3A7

Target: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Andere Bezeichnung: CYP3A7 (CYP3A7 Produkte)

Synonyme: CP37 antikoerper, CYPIIIA7 antikoerper, P450-HFLA antikoerper, cytochrome P450, family 3, subfamily A, polypeptide 7 antikoerper, cytochrome P450 family 3 subfamily A member 7 antikoerper, CYP3A7 antikoerper

Hintergrund: CYP3A7 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1.This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
Alias Symbols: CP37, P450-HFLA, CYPIIIA7
Protein Size: 503

Molekulargewicht: 57 kDa

Gen-ID: 1551

NCBI Accession: NM_000765, NP_000756

UniProt: P24462

Pathways: Steroid Hormone Biosynthesis