Tropomyosin Antikörper (Middle Region)

Produktnummer ABIN2776817

Produktdetails anti-Tropomyosin Antikörper

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tropomyosin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LKEAETRAEF AERSVTKLEK SIDDLEDQLY QQLEQNRRLT NELKLALNED

Homologie: Human: 100%, Mouse: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TPM1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TPM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 245 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Tropomyosin

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Andere Bezeichnung: TPM1 (TPM1 Produkte)

Synonyme: alpha-fTM antikoerper, Tm7 antikoerper, tpm1 antikoerper, MGC84844 antikoerper, AA986836 antikoerper, AI854628 antikoerper, TM2 antikoerper, Tm3 antikoerper, Tmpa antikoerper, Tpm-1 antikoerper, alpha-TM antikoerper, Alpha-tm antikoerper, Tma2 antikoerper, Tmsa antikoerper, TPM1 antikoerper, fb37a09 antikoerper, tm antikoerper, wu:fb37a09 antikoerper, CH1 antikoerper, alpha-tm antikoerper, alpha-tropomyosin antikoerper, C15orf13 antikoerper, CMD1Y antikoerper, CMH3 antikoerper, HTM-alpha antikoerper, TMSA antikoerper, TPMA antikoerper, Tm1 antikoerper, zgc:171719 antikoerper, zgc:55951 antikoerper, zgc:77009 antikoerper, tropomyosin 1 (alpha) antikoerper, tropomyosin antikoerper, tropomyosin 1 antikoerper, tropomyosin 1, alpha antikoerper, alpha-tropomyosin antikoerper, tropomyosin 1 L homeolog antikoerper, TPM1 antikoerper, tm7 antikoerper, Tpm1 antikoerper, tpma antikoerper, tpm1.L antikoerper, Smp_044010.2 antikoerper, LOC732984 antikoerper, tpm1 antikoerper

Hintergrund: TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
Alias Symbols: C15orf13, HTM-alpha, TMSA, CMH3, CMD1Y
Protein Interaction Partner: GOLGA2, CAGE1, C1orf216, SYCE1, KXD1, TFPT, MAD1L1, TPM4, TP53, TNNT1, UBC, MDM2, ETFA, FOXK1, KIAA1598, PPP6R3, APPL2, CDC37, MGEA5, STUB1, ABI2, DNAJC7, HSP90B1, PARK2, LRCH3, PAN2, TGFBR1, SPTBN1, ATF2, MDC1, BRCA1, PPP4R2, SRXN1, NUDCD2, RBM15, THOC2,
Protein Size: 245

Molekulargewicht: 28 kDa

Gen-ID: 7168

NCBI Accession: NM_001018008, NP_001018008

UniProt: Q7Z6L8

Pathways: Regulation of Actin Filament Polymerization