SLC12A1 Antikörper (N-Term)
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- Target Alle SLC12A1 Antikörper anzeigen
- SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Ratte, Human, Maus, Hund, Schwein, Kaninchen, Meerschweinchen, Rind (Kuh), Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SLC12A1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- NEKKSRGFFN YQASIFAENF GPRFTKGEGF FSVFAIFFPA ATGILAGANI
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SLC12A1. It was validated on Western Blot and immunohistochemistry.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SLC12A1
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 430 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice." in: American journal of physiology. Renal physiology, Vol. 311, Issue 4, pp. F752-F762, (2016) (PubMed).
: "Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 5, pp. 834-41, (2012) (PubMed).
: "Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells." in: American journal of physiology. Renal physiology, Vol. 295, Issue 4, pp. F1158-65, (2008) (PubMed).
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Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice." in: American journal of physiology. Renal physiology, Vol. 311, Issue 4, pp. F752-F762, (2016) (PubMed).
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- Target
- SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
- Andere Bezeichnung
- SLC12A1 (SLC12A1 Produkte)
- Synonyme
- slc12a1 antikoerper, SLC12A1 antikoerper, DKFZp469A2020 antikoerper, BSC1 antikoerper, NKCC2 antikoerper, Nkcc2 antikoerper, AI788571 antikoerper, D630042G03Rik antikoerper, mBSC1 antikoerper, urehr3 antikoerper, si:ch211-220f12.1 antikoerper, solute carrier family 12 member 1 antikoerper, solute carrier family 12, member 1 antikoerper, si:ch211-220f12.1 antikoerper, SLC12A1 antikoerper, Slc12a1 antikoerper
- Hintergrund
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The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
Alias Symbols: BSC1, MGC48843, NKCC2
Protein Interaction Partner: STK39, OXSR1,
Protein Size: 430 - Molekulargewicht
- 47 kDa
- Gen-ID
- 6557
- NCBI Accession
- NM_000338
- UniProt
- Q8IUN5
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