TRPM8 Antikörper (N-Term)
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- Target Alle TRPM8 Antikörper anzeigen
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus, Meerschweinchen, Kaninchen, Hund, Pferd, Schwein, Rind (Kuh)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TRPM8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTI QDSNYGGKIP
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against TRPM8. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM8
- Top Product
- Discover our top product TRPM8 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1104 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- Andere Bezeichnung
- TRPM8 (TRPM8 Produkte)
- Synonyme
- TRPM8 antikoerper, trpp8 antikoerper, ltrpc6 antikoerper, trpm8b antikoerper, LTRPC6 antikoerper, TRPP8 antikoerper, CMR1 antikoerper, LTrpC-6 antikoerper, Trp-p8 antikoerper, transient receptor potential cation channel subfamily M member 8 antikoerper, transient receptor potential cation channel subfamily M member 8b L homeolog antikoerper, transient receptor potential cation channel, subfamily M, member 8 antikoerper, TRPM8 antikoerper, trpm8b.L antikoerper, Trpm8 antikoerper
- Hintergrund
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TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Alias Symbols: LTRPC6, MGC2849, TRPP8
Protein Interaction Partner: CHAMP1, TXLNA, ZC3H18, RTF1, SF3A3, USP10,
Protein Size: 1104 - Molekulargewicht
- 128 kDa
- Gen-ID
- 79054
- NCBI Accession
- NM_024080, NP_076985
- UniProt
- Q7Z2W7
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