CACNB4 Antikörper (C-Term)

Produktnummer ABIN2776098

Produktdetails anti-CACNB4 Antikörper

Target: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNB4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LEAYWRATHT TSSTPMTPLL GRNLGSTALS PYPTAISGLQ SQRMRHSNHS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CACNB4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CACNB4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 486 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CACNB4

Target: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Andere Bezeichnung: CACNB4 (CACNB4 Produkte)

Synonyme: CAB4 antikoerper, CACNLB4 antikoerper, EA5 antikoerper, EIG9 antikoerper, EJM antikoerper, EJM4 antikoerper, EJM6 antikoerper, 3110038O15Rik antikoerper, Cchb4 antikoerper, lethargic antikoerper, lh antikoerper, CACNB4 antikoerper, cacnb4.2 antikoerper, calcium voltage-gated channel auxiliary subunit beta 4 antikoerper, calcium channel, voltage-dependent, beta 4 subunit antikoerper, calcium channel, voltage-dependent, beta 4a subunit antikoerper, CACNB4 antikoerper, Cacnb4 antikoerper, cacnb4.1 antikoerper, cacnb4 antikoerper, cacnb4a antikoerper

Hintergrund: CACNB4 is a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. CACNB4 plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Alias Symbols: CAB4, CACNLB4, EA5, EJM, EIG9, EJM4, EJM6
Protein Interaction Partner: CBX3, FASLG, REM1, MED31, TBL3, CACNA1A, PTN,
Protein Size: 486

Molekulargewicht: 55 kDa

Gen-ID: 785

NCBI Accession: NM_001005747, NP_001005747

Pathways: cAMP Metabolic Process, Skeletal Muscle Fiber Development