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NFKBIB Antikörper (Middle Region)

NFKBIB Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen, Schwein WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2775761
  • Target Alle NFKBIB Antikörper anzeigen
    NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
    Bindungsspezifität
    • 30
    • 13
    • 10
    • 10
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 107
    • 40
    • 34
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen, Schwein
    Wirt
    • 100
    • 8
    Kaninchen
    Klonalität
    • 92
    • 16
    Polyklonal
    Konjugat
    • 54
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser NFKBIB Antikörper ist unkonjugiert
    Applikation
    • 80
    • 39
    • 30
    • 24
    • 23
    • 16
    • 13
    • 7
    • 4
    • 3
    • 1
    Western Blotting (WB)
    Sequenz
    PILARLLRAH GAPEPEGEDE KSGPCSSSSD SDSGDEGDEY DDIVVHSSRS
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 91%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against NFKBIB. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NFKBIB
    Top Product
    Discover our top product NFKBIB Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 356 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
    Andere Bezeichnung
    NFKBIB (NFKBIB Produkte)
    Synonyme
    NFKBIB antikoerper, IKB-beta antikoerper, IKappaBbeta antikoerper, IkB antikoerper, IkBb antikoerper, IKBB antikoerper, TRIP9 antikoerper, NFKB inhibitor beta antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antikoerper, NFKBIB antikoerper, Nfkbib antikoerper
    Hintergrund
    Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c
    Alias Symbols: IKBB, TRIP9
    Protein Interaction Partner: VPS52, UBC, BAG3, TSPAN1, GIT2, RELA, REL, CSNK2A1, CDC25A, BAK1, APP, ZBTB7A, DNAJA3, IKBKB, CHUK, BRAP, IKBKG, TRE17, NFKBIA, NCOR2, PPARG, ESR2, POLR1D, POLR1E, POLR1A, POLR1C, POLR2H, NKIRAS2, POLR1B, NKIRAS1, LRPPRC, RASAL2, MTIF2, BTRC, CUL1, SKP1,
    Protein Size: 356
    Molekulargewicht
    38 kDa
    Gen-ID
    4793
    NCBI Accession
    NM_002503, NP_002494
    UniProt
    Q15653
    Pathways
    NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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