Angiotensin II Type-1 Receptor Antikörper (N-Term)

Produktnummer ABIN2775286

Produktdetails anti-Angiotensin II Type-1 Receptor Antikörper

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Hund, Kaninchen, Meerschweinchen, Rind (Kuh), Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiotensin II Type-1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ILNSSTEDGI KRIQDDCPKA GRHNYIFVMI PTLYSIIFVV GIFGNSLVVI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against AGTR1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AGTR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 359 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Angiotensin II Type-1 Receptor

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Andere Bezeichnung: AGTR1 (AGTR1 Produkte)

Synonyme: AG2S antikoerper, AGTR1A antikoerper, AGTR1B antikoerper, AT1 antikoerper, AT1AR antikoerper, AT1B antikoerper, AT1BR antikoerper, AT1R antikoerper, AT2R1 antikoerper, AT2R1A antikoerper, AT2R1B antikoerper, HAT1R antikoerper, 1810074K20Rik antikoerper, AI551199 antikoerper, AT1a antikoerper, Agtr-1a antikoerper, Agtr1 antikoerper, Angtr-1a antikoerper, AT1A antikoerper, XAT-1 antikoerper, agtr1-A antikoerper, agtr1.2 antikoerper, AT1-R antikoerper, at1 antikoerper, AGTR1 antikoerper, Agtr-1b antikoerper, Angtr-1b antikoerper, agtr1 antikoerper, agtr1-a antikoerper, agtr1-b antikoerper, xAT antikoerper, angiotensin II receptor type 1 antikoerper, angiotensin II receptor, type 1a antikoerper, angiotensin II receptor type 1 S homeolog antikoerper, uncharacterized AGTR1 antikoerper, angiotensin II receptor, type 1b antikoerper, angiotensin II receptor type 1 L homeolog antikoerper, AGTR1 antikoerper, Agtr1a antikoerper, agtr1.S antikoerper, Agtr1 antikoerper, Agtr1b antikoerper, agtr1.L antikoerper

Hintergrund: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.
Alias Symbols: AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1R
Protein Interaction Partner: PDE6H, GNB2L1, HTR2B, ARRB2, ARRB1, JAK2, TRAF3, MAPK1, AGTRAP, DNAJC14, THOP1, GRK5, GPRASP1, HRAS, RAB5A, PLCG1, RAF1, NOS3, EGFR, BDKRB2, ADRBK2, ADRBK1, AGT, ZBTB16,
Protein Size: 359

Molekulargewicht: 41 kDa

Gen-ID: 185

NCBI Accession: NM_004835, NP_004826

UniProt: P30556

Pathways: JAK-STAT Signalweg, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour