TWEAK Antikörper (N-Term)

Produktnummer ABIN2774826

Produktdetails anti-TWEAK Antikörper

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Pferd, Hund, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TWEAK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LGLLLAVVSL GSRASLSAQE PAQEELVAEE DQDPSELNPQ TEESQDPAPF

Homologie: Dog: 79%, Horse: 93%, Human: 100%, Mouse: 83%, Rabbit: 83%, Rat: 86%, Zebrafish: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against TNFSF12. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF12

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 249 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TWEAK

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Andere Bezeichnung: TNFSF12 (TNFSF12 Produkte)

Synonyme: APO3L antikoerper, DR3LG antikoerper, TWEAK antikoerper, Apo3l antikoerper, Dr3l antikoerper, Dr3lg antikoerper, Tweak antikoerper, TNF superfamily member 12 antikoerper, tumor necrosis factor (ligand) superfamily, member 12 antikoerper, TNFSF12 antikoerper, Tnfsf12 antikoerper

Hintergrund: TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Protein Interaction Partner: DDIT3, TNFSF13B, LYN, OTUB1, TRAF2, BIRC2, AGGF1, TNFRSF12A, TNFRSF25,
Protein Size: 249

Molekulargewicht: 17 kDa

Gen-ID: 8742

NCBI Accession: NM_003809, NP_003800

UniProt: O43508

Pathways: Apoptose