CTDSP2 Antikörper (Middle Region)

Produktnummer ABIN2774003

Produktdetails anti-CTDSP2 Antikörper

Target: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTDSP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 91%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CTDSP2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CTDSP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 271 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CTDSP2

Target: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Andere Bezeichnung: CTDSP2 (CTDSP2 Produkte)

Synonyme: fb16c04 antikoerper, wu:fb16c04 antikoerper, zgc:77714 antikoerper, MGC68415 antikoerper, CTDSP2 antikoerper, OS4 antikoerper, PSR2 antikoerper, SCP2 antikoerper, AI586070 antikoerper, D10Ertd73e antikoerper, OS-4 antikoerper, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 antikoerper, CTD small phosphatase 2 L homeolog antikoerper, CTD small phosphatase 2 antikoerper, ctdsp2 antikoerper, ctdsp2.L antikoerper, CTDSP2 antikoerper, Ctdsp2 antikoerper

Hintergrund: CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
Alias Symbols: OS4, PSR2, SCP2
Protein Interaction Partner: CDCA3, UBC, AR, SNAI1, POLR2A,
Protein Size: 271

Molekulargewicht: 31 kDa

Gen-ID: 10106

NCBI Accession: NM_005730, NP_005721

UniProt: O14595

Pathways: ER-Nucleus Signaling