CACNA1C Antikörper

Produktnummer ABIN2763649

Produktdetails anti-CACNA1C Antikörper

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNA1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Produktmerkmale: Voltage-Dependent T-Type Calcium Channel, alpha1G subunit, Cncna1G,Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1g gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. alpha(1G) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway.

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from the rat alpha1G calcium channel conjugated to KLH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu CACNA1C

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Andere Bezeichnung: Calcium Channel (CACNA1C Produkte)

Synonyme: CACH2 antikoerper, CACN2 antikoerper, CACNL1A1 antikoerper, CCHL1A1 antikoerper, CaV1.2 antikoerper, LQT8 antikoerper, TS antikoerper, Cav1.2 antikoerper, Cchl1a1 antikoerper, MBC antikoerper, MELC-CC antikoerper, RATIVS302 antikoerper, isl antikoerper, C-LTCC antikoerper, CHCACHA1C antikoerper, ICA antikoerper, cav1.2 antikoerper, ca(v)1.2 antikoerper, CAV1.2 antikoerper, BCR antikoerper, rbc antikoerper, calcium voltage-gated channel subunit alpha1 C antikoerper, calcium channel, voltage-dependent, L type, alpha 1C subunit antikoerper, voltage-dependent L-type calcium channel subunit alpha-1C antikoerper, calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog antikoerper, Red blood cell count antikoerper, RNA, 7SL, cytoplasmic 263, pseudogene antikoerper, CACNA1C antikoerper, Cacna1c antikoerper, cacna1c antikoerper, LOC100442085 antikoerper, cacna1c.S antikoerper, RBC antikoerper, RN7SL263P antikoerper

Pathways: Hormone Transport, Carbohydrate Homeostasis