Macrophage Mannose Receptor 1 Antikörper

Produktnummer ABIN2749170

Produktdetails anti-Macrophage Mannose Receptor 1 Antikörper

Target: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Macrophage Mannose Receptor 1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Purified human mannose receptor

Klon: 15-2

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Western blotting: Recommended dilution: 1-2 μg/mL, non-reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-Macrophage Mannose Receptor 1 Antikörper (ABIN2749170)

Sindrilaru, Peters, Wieschalka, Baican, Baican, Peter, Hainzl, Schatz, Qi, Schlecht, Weiss, Wlaschek, Sunderkötter, Scharffetter-Kochanek: "An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice." in: The Journal of clinical investigation, Vol. 121, Issue 3, pp. 985-97, (2011) (PubMed).

Shan, Klasse, Banerjee, Dey, Iyer, Dionisio, Charles, Campbell-Gardener, Olson, Sanders, Moore: "HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells." in: PLoS pathogens, Vol. 3, Issue 11, pp. e169, (2007) (PubMed).

Sturge, Todd, Kogianni, McCarthy, Isacke: "Mannose receptor regulation of macrophage cell migration." in: Journal of leukocyte biology, Vol. 82, Issue 3, pp. 585-93, (2007) (PubMed).

Torrelles, Azad, Schlesinger: "Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 3, pp. 1805-16, (2006) (PubMed).

Chang, Hsu, Lin, Chio, Chiu, Chen, Lin, Hsieh: "Modulation of macrophage differentiation and activation by decoy receptor 3." in: Journal of leukocyte biology, Vol. 75, Issue 3, pp. 486-94, (2004) (PubMed).

Details zu Macrophage Mannose Receptor 1

Target: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Andere Bezeichnung: CD206 (MRC1 Produkte)

Synonyme: CD206 antikoerper, CLEC13D antikoerper, CLEC13DL antikoerper, MMR antikoerper, MRC1L1 antikoerper, bA541I19.1 antikoerper, AW259686 antikoerper, MR antikoerper, mrc1 antikoerper, MGC86525 antikoerper, MRC1 antikoerper, MRC1L-A antikoerper, mannose receptor C-type 1 antikoerper, mannose receptor, C type 1 antikoerper, mannose receptor C-type 1 L homeolog antikoerper, mediator of replication checkpoint 1 antikoerper, MRC1 antikoerper, Mrc1 antikoerper, mrc1.L antikoerper, mrc1 antikoerper

Hintergrund: Mannose receptor C-type 1,CD206 (macrophage mannose receptor, MMR), also known as mannose receptor C1 (MRC1), is a type I transmembrane glycoprotein serving as pattern recognition receptor for carbogydrate groups on the surface of bacteria, fungi and other pathogens. Expressed mainly on tissue macrophages and dendritic cells, CD206 mediates endocytosis of these pathogens and presentation of their antigens to the adaptive immune system. CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.,MMR, MRC1, CLEC13DL

Gen-ID: 4360

UniProt: P22897