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CD94 Antikörper (PE)

KLRD1 Reaktivität: Human FACS Wirt: Maus Monoclonal HP-3D9 PE
Produktnummer ABIN2749144
  • Target Alle CD94 (KLRD1) Antikörper anzeigen
    CD94 (KLRD1) (Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1))
    Reaktivität
    • 59
    • 34
    • 2
    • 1
    Human
    Wirt
    • 52
    • 22
    • 15
    • 1
    Maus
    Klonalität
    • 53
    • 36
    Monoklonal
    Konjugat
    • 28
    • 13
    • 8
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD94 Antikörper ist konjugiert mit PE
    Applikation
    • 43
    • 34
    • 26
    • 13
    • 13
    • 11
    • 10
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody HP-3D9 recognizes an extracellular epitope of CD94, a 70 kDa type II transmembrane glycoprotein expressed on NK cells, NK-T cells, and subsets of CD8+ T cells and gamma/delta T cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Cultured human NK cells
    Klon
    HP-3D9
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product KLRD1 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Yu, Mao, Wei, Hughes, Zhang, Park, Liu, McClory, Marcucci, Trotta, Caligiuri: "CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets." in: Blood, Vol. 115, Issue 2, pp. 274-81, (2010) (PubMed).

    Hallermalm, Seki, De Geer, Motyka, Bleackley, Jager, Froelich, Kiessling, Levitsky, Levitskaya: "Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 6, pp. 3766-74, (2008) (PubMed).

    Bovenschen, Van De Kerkhof, Gerritsen, Seyger: "The role of lesional T cells in recalcitrant psoriasis during infliximab therapy." in: European journal of dermatology : EJD, Vol. 15, Issue 6, pp. 454-8, (2005) (PubMed).

    Wada, Matsumoto, Maenaka, Suzuki, Yamamoto: "The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues." in: European journal of immunology, Vol. 34, Issue 1, pp. 81-90, (2004) (PubMed).

    Ntrivalas, Kwak-Kim, Gilman-Sachs, Chung-Bang, Ng, Beaman, Mantouvalos, Beer: "Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology." in: Human reproduction (Oxford, England), Vol. 16, Issue 5, pp. 855-61, (2001) (PubMed).

    Seo, Tokura, Ishihara, Takeoka, Tagawa, Takigawa: "Disordered expression of inhibitory receptors on the NK1-type natural killer (NK) leukaemic cells from patients with hypersensitivity to mosquito bites." in: Clinical and experimental immunology, Vol. 120, Issue 3, pp. 413-9, (2000) (PubMed).

    Phillips, Chang, Mattson, Gumperz, Parham, Lanier: "CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes." in: Immunity, Vol. 5, Issue 2, pp. 163-72, (1996) (PubMed).

  • Target
    CD94 (KLRD1) (Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1))
    Andere Bezeichnung
    CD94 (KLRD1 Produkte)
    Synonyme
    CD94 antikoerper, CD94-B antikoerper, Cd94 antikoerper, killer cell lectin like receptor D1 antikoerper, killer cell lectin-like receptor subfamily D, member 1 antikoerper, killer cell lectin-like receptor, subfamily D, member 1 antikoerper, KLRD1 antikoerper, Klrd1 antikoerper
    Hintergrund
    Killer cell lectin like receptor D1,CD94, also known as KLRD1 (killer cell lectin-like receptor D1), is a transmembrane glycoprotein of the C-type lectin family, which forms disulfide-linked heterodimers with NKG2A, B, C, E, H proteins, constituting functionally distinct receptors of NK cells and related cell types. CD94/NKG2A and CD94/NKG2B heterodimers serve as inhibitory, whereas CD94/NKG2C and CD94/NKG2E as activating receptors. The ligand for CD94/NKG2 complexes has been identified as HLA-E. Extent of CD94 expression on NK cell surface can be used to demonstrate their progress through the differentiation process.,KLR-D1, KLRD1, KCLLRD1
    Gen-ID
    3824
    UniProt
    Q13241
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