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CD137 Antikörper (PE)

TNFRSF9 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal 4B4-1 PE
Produktnummer ABIN2749106
  • Target Alle CD137 (TNFRSF9) Antikörper anzeigen
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Reaktivität
    • 96
    • 42
    • 26
    • 8
    • 3
    • 1
    • 1
    Human, Non-Human Primate
    Wirt
    • 45
    • 40
    • 12
    • 11
    • 5
    • 1
    Maus
    Klonalität
    • 62
    • 47
    • 3
    Monoklonal
    Konjugat
    • 60
    • 14
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD137 Antikörper ist konjugiert mit PE
    Applikation
    • 72
    • 59
    • 54
    • 15
    • 14
    • 12
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Recombinant human CD137 ectodomain
    Klon
    4B4-1
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product TNFRSF9 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Yi, Zhao, Wang, Dai, Hellström, Hellström, Zhang: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." in: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).

    Bellarosa, Bressan, Bigioni, Parlani, Maggi, Binaschi: "SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line." in: International journal of oncology, Vol. 41, Issue 4, pp. 1486-94, (2013) (PubMed).

    Fernández Do Porto, Jurado, Pasquinelli, Alvarez, Aspera, Musella, García: "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis." in: Immunology and cell biology, Vol. 90, Issue 4, pp. 449-56, (2012) (PubMed).

    Chan, Voskens, Lin, Schindler, Azimzadeh, Wang, Taylor, Strome, Schulze: "Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models." in: Journal of molecular recognition : JMR, Vol. 22, Issue 3, pp. 242-9, (2009) (PubMed).

  • Target
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Andere Bezeichnung
    CD137 / 4-1BB (TNFRSF9 Produkte)
    Synonyme
    TNFRSF9 antikoerper, zgc:136557 antikoerper, 4-1BB antikoerper, CD137 antikoerper, CDw137 antikoerper, ILA antikoerper, A930040I11Rik antikoerper, AA408498 antikoerper, AI325004 antikoerper, Cd137 antikoerper, Ly63 antikoerper, tumor necrosis factor receptor superfamily member 9 antikoerper, TNF receptor superfamily member 9 antikoerper, tumor necrosis factor receptor superfamily, member 9a antikoerper, tumor necrosis factor receptor superfamily, member 9 antikoerper, TNFRSF9 antikoerper, tnfrsf9a antikoerper, Tnfrsf9 antikoerper
    Hintergrund
    TNF receptor superfamily member 9,CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.,TNFRSF9, 41BB, 4-1BB, MGC2172
    Gen-ID
    3604
    UniProt
    Q07011
    Pathways
    Cancer Immune Checkpoints
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